Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"M cells."”.
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The morphology and function of Peyer's patches in the dog
… phosphates positive enterocytes and scattered M cells with low alkaline phosphatase activity, ileal dome epithelia predominantly consisted of M cells and few enterocytes. The domes of PPs contained numerous IgG plasma cells and a few or moderate number of IgA plasma cells.
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Functional Dynamics of Primate Retinal Ganglion Cells
… signals. The responses of retinal ganglion cells to such signals provide the means to explore such processing in the retina. Most primate retinal ganglion cells fall into two broad classes, M and P, which have many anatomical and physiological differences. The responses of M and P cells to …
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Interaction of Salmonella typhimurium and Listeria monocytogenes with the murine host
… typhimurium and Shigella flexneri, use M cells, found only within the follicle associated epithelium (FAE) that overlies Peyer’s patches and other lymphoid follicles, to enter the host. This study is primarily an investigation into the interaction of S. typhimurium and Listeria …
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The invasin IbeA and its role in Adherent-Invasive Escherichia coli (AIEC) pathogenesis
… adhesion and invasion of intestinal epithelial cells evaluated. The role that this outer membrane protein, IbeA, plays in intra-macrophage survival was also assessed. Compared to the wild-type, AIEC ∆ibeA presented reduced invasion to not only enterocytes but also M cells, which correlated with …
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The effect of doxorubicin on the U2OS cell cycle
Treatment of U20S cells with the chemotherapeutic drug Doxorubicin results in either apoptosis or cellular senescence. The pathway the cell takes is dependent upon the dosage of Doxorubicin administered to the cells. When a 10 [mu]M dose is administered Topoisomerase II is inhibited resulting in …
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Study of Rest As A Negative Regulator of P16Ink4A
… with onset of neuronal differentiation in these cells. REST has been widely studied as a negative regulator of neuronal differentiation genes. Our recent work identified a novel role for REST in control of cell proliferation. However, the underlying molecular mechanism(s) are not known and is a …
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Energetics of maize C4 physiology under light limiting conditions
… regeneration vary between BS and Mesophyll (M) cells. For these anatomical and biochemical complexities, C4 plants are highly sensitive to light conditions. Under limiting light, the activity of the CCM generally decreases, causing an increase in leakiness, (Φ), the ratio of CO2 retrodiffusing …
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Assessing the accuracy of the MODIS LAI 1-km product in southeastern United States loblolly pine plantations: Accounting for measurement variance from ground to satellite
… m--30 m), and (3) the aggregation of these 30 m cells to 1 km spatial resolution, matching the resolution of the MODIS product and enabling a comparison of the two LAI values (Morisette et al. 2006). This research assessed the uncertainty associated with the creation of the high-resolution LAI …
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Low-stress multiwire stringing and cell interconnection for thin silicon solar cells and modules
In the field of silicon solar cells and modules, multiwire interconnection technologies have received significant attention due to their performance advantages over conventional buswires. Realization of these benefits has been limited due to additional complex manufacturing steps to create an …
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Multiple-scale habitat models of benthic fish abundance in riffles
… correlated. At the microhabitat scale (45 m² cells), differential use of depth, velocity, substrate, and siltation level by all three species during summer low flows was evident. Habitat use characteristics were not transferable, as depths and velocities associated with high fish densities …
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Hedgehog signaling: a potential therapeutic target for non-small cell lung cancer
… molecular characteristics with cancer stem-like cells, contributes to lung cancer treatment failure. In view of the fact that EMT process has been implicated in the two important biological processes that are accountable for cancer-related deaths; the progression of cancer cells to a distant …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… of cancer-related deaths occur because cancer cells metastasize, i.e. invade the surrounding tissue, travel throughout the body, and form tumors at distant organs. Metastasis is often fueled by Epithelial-to-Mesenchymal Transition (EMT) that enables cells to migrate and invade, and its reverse …
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Micro/Nanoencapsulation of Proteins Within Alginate/Chitosan Matrix by Spray Drying
… less than 5µm are able to be taken up by the M cells of Peyer’s patches found in intestinal mucosa . However, the current methodologies to produce particles within desired range involves organic solvents and several steps. In this study, spray drying was investigated as a microencapsulation …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… potential strategy for targeting TAMs. CAR-M cells can maintain a sustainable M1 phenotype and polarize M2 macrophages toward an M1 phenotype. However, this process is costly, time-consuming, and carries risks like insertional mutagenesis, making it inaccessible for many families. One …
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Somatosensory processing by rat medial pontomedullary reticular formation neurones : responses to innocuous and noxious thermal and mechanical stimuli
… excited 188 of 235 (80%) PMRF neurones (ON-m cells), and inhibited 40 (17%, OFF-m cells). Seven cells (3%) had mosaic receptive fields of excitation and inhibition (complex responses, CX-m). Twenty-eight percent of neurones were responsive to both weak and intense stimuli (mixed neurones). The …
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Dock180/Elmo proteins are critical regulators of phagocytosis,macropinocytosis and chemotaxis in Dictyostelium
… movement. Aggregation competent Dictyostelium cells can detect and move up CAMP gradients. cAMP stimulation causes a transient localized increase in phosphatidyl inositol (3,4,5) tris phosphate (PIP3) concentration in the plasma membrane at the cell's leading edge. PIP3 binding domain …
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Genetic Circadian Mosaics and the Clock Network’s Contributions to Sleep
… activity have been referred to as the M-cells, the group of neurons known to rescue evening anticipatory locomotor activity have been termed the E-cells. In this study I have selectively reinstated the Period (PER) protein using the Gal4-UAS system in specific subsets of the circadian …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… cell sampling, but not of sampling by M cells. In inflamed mucosal tissue, both confocal and electron microscopic analysis suggested an enhanced uptake of lactococci through the paracellular route, which is likely to be a result of the damaged mucosal barrier. We were able to show the …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… presence of hormone-releasing enteroendocrine cells (EECs), which represent only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such as nutrient digestion and absorption, intestinal motility, …
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