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Showing 1 to 4 of 4 for “"Müllerian duct"”.
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Genetic Regulation of Müllerian Duct Regression
… progenitor tissues for both male and female reproductive tract organs before they fully differentiate into a male or female tract. The progenitor tissue for the male reproductive tract is known as the Wolffian duct (WD), and the progenitor tissue for the female reproductive tract is the Müllerian …
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The role of Wt1 in Müllerian duct development
… where we deleted <em>Wt1</em> in the Müllerian duct (MD) mesenchyme using a novel conditional null reporter allele, <em>Wt1 flox-RFP</em>. This allele utilizes the Cre-lox system to delete exons 8 and 9 of <em>Wt1</em>, disrupting the DNA binding capability of the protein. …
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A four-and-a-half LIM protein FHL2 acts as a coactivator for the Wilms' tumor suppressor WT1 during gonadal differentiation
… sex determination is the maintenance of the Müllerian duct in females which gives rise to oviduct, uterus and the upper part of vagina and its regression in males caused by the expression of Müllerian inhibiting substance (MIS). The Wilms' tumor suppressor (WT1) and the orphan nuclear …
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Dissecting the spatio-temporal development of the human reproductive tract
The human reproductive tract plays a crucial role in fertility and overall health due to the systemic effect of sex hormones. Its development depends on tightly regulated processes of sex differentiation, spatial patterning, and morphogenesis, which, when disrupted, can lead to congenital …