Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Müller cells"”.
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Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma
… on the survival and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to different levels of OGD using a custom-built chamber to control oxygen levels. Cell …
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Aquaporin 4 and Kir4.1 Distribution in Retinal Glial Cells of Normal Macaque Eyes and Eyes with Experimental Glaucoma
… inward rectifying channel (Kir4.1) in the Müller glia and astrocytes of the normal macaque monkey retina and to see how the distribution changed in eyes with experimental glaucoma. Methods: Five Rhesus macaque monkeys, ranging in age from 7 to 11 years, had experimental glaucoma induced in …
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The role of Interleukin-33 in retinal degenerative diseases
Müller cells are the principal glial cells in the retina, and they play an essential role in maintaining retinal homeostasis by supporting neuronal and vascular function. In disease settings, dysregulation of Müller cells leading to their prolonged activation is known to be critical for …
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Development of a Workflow to study Neuronal Injury In Vivo in the Retina and In Vitro in Collagen Hydrogels
… an in vitro model of compression to neuronal cells was developed in Aim 2. The first aim of the study employed an established preclinical blast model to expose the entire body of rats to three blast waves, each one hour apart. Immunohistochemistry was performed on retinas isolated twenty-nine …
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An Ex Vivo Model For The Assessment Of Drug Toxicity On The Human Retina
… on the human retinal cell lines MIO-M1 (Müller cells) and ARPE19 (RPE cells), and CHQ on the human organotypic retinal culture (HORC) using the LDH and MTS assays. TUNEL, Western blotting and QRT-PCR were also used to investigate the effect of CHQ on the HORC, and CDK expression …
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Genetic Regulation of Retinal Cells by Variation of Underlying Elastic Modulus
… medicine occurred when it was noticed that when cells are plated on substrates of different stiffnesses undergo certain conformational changes in their cytoskeleton. Specifically, the tension in cytoskeleton of the cells on the substrates increased with stiffness. Many different cell types were …
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Calcium-dependent mechanisms in the chicken retina
Multiple classes of retinal amacrine cells use L-type Ca2+ channels to mediate synaptic transmission. I have used whole cell voltage clamp recordings from primary cultures of amacrine cells to investigate the regulation of these channels. In this study, I show that inhibiting mitochondrial calcium …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… apoptosis in vitro in both retinal endothelial cells (REC) and Müller cells and did so at a significantly lower concentration than isoproterenol, deeming it the most effective compound.</p> <p>Objective. We evaluated the effectiveness of Compound 49b to prevent and delay changes associated with …
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Physikochemische und biologische Charakterisierung von texturiertem Silikon als Grundlage für die Entwicklung eines Retina-Patchs
… retinal break and be fixed by proliferation of Müller cells (glial cells) located in the retina in the pores of the Retina-Patch. In this study, it was investigated whether textured silicone (TS) complies with the basic requirements to use it for the development of the ophthalomologic product …