Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Lysyl Oxidase"”.
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Examining The Role Of Lysyl Oxidase Enzymes In Atrial Fibrillation Induced By Volume Overload
… results from collagen stabilization by the Lysyl Oxidases (LOX) family of enzymes. To investigate this relationship, we established a murine aortic regurgitation (AR) model, which induces atrial stretch. AR mice exhibited increased AF susceptibility, decreased atrial refractoriness (AERP), …
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Mechanisms of Copper-Dependent Notochord Formation in Zebrafish
… in copper-deficient zebrafish results from lysyl oxidase cuproenzyme inhibition. Four lysyl oxidase family members are expressed throughout the developing zebrafish notochord, including <italic>loxl1</italic> and <italic>loxl5b</italic>. Morpholino antisense experiments reveal that knockdown …
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The influence of maternal nicotine exposure on development lung as gas exchanger: the protective effect of copper
… lesions. Elastic tissue is catalysed by lysyl oxidase, an extracellular, copper dependent en4rmq from its soluble to its insoluble state. It is suggested that lesions occur in lturgs exposed to nicotine because of a decrease in lung copper content, which will, in turn, cause decreased …
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The Role of Extracellular Matrix Rigidity and Altered microRNA Expression In TGF-beta-Mediated Breast Cancer Progression
… of the extracellular crosslinking enzyme, lysyl oxidase (LOX), which regulates desmoplastic reactions and metastasis. We show that TGF-beta induces the synthesis and secretion of LOX from normal and malignant MECs, and in breast cancers produced in mice. Additionally, antagonizing LOX …
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Differential Gene Expression in Response to Hypoxia and Acidosis in Chest Wall Deformities and Chondrosarcoma
… pathway. Two genes, factor 3 <em>F3</em> and lysyl oxidase <em>LOX</em>, were chosen based on high fold change within the preliminary study; two replicate experiments were repeated for a total of 12 patient samples. Our analysis showed no significant change in any cell type compared to the …
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… old mice were co-infused with Ang-II and BAPN, a lysyl oxidase inhibitor, to induce AAA. We found that mice lacking the main structural protein of caveolae, caveolin-1, did not develop AAA compared to WT animals in spite of hypertensive blood pressures measured by telemetry in both groups. This …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… genes and biosynthetic enzymes such as lysyl oxidase (LOX) synthesis. This excess synthesis and crosslinking of extracellular matrix (ECM) components cause AT fibrosis. Although fibrosis is a hallmark of obese AT, the role of fibroblasts, cells known to regulate fibrosis in other …
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An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development
… which suggested that nicotine may impair lysyl oxidase activity by reducing the lung copper content in the lungs of rats that were exposed to nicotine via the placenta and mother’s milk. It was found that although maternal nicotine exposure had no significant effect on the growth …
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Development and characterization of anti-EGFR protein-drug conjugates for tumor therapy
… analysis. Also, expression of the human lysyl oxidase-like 2 (hLOXL2) and the amine oxidase from _Escherichia coli_ (ECAO) was established, which can be used for the scanning of possible recognition motifs that would allow the site-specific incorporation of allysine into protein-tags. <br …
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New Designs of Electrochemical H2O2 Based Biosensors For Advanced Medical Diagnosis
… cancer diagnosis by a potential biomarker, lysyl oxidase like 2 (LOXL2), on the developed electrochemical biosensor. The aberrant LOXL2 expression can be observed in poorly differentiated, high-grade tumors, and, predicted for the acquisition of chemo-resistance, recurrent phenotypes, and …
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Therapeutic targeting of the ATP7A copper transporter in cancer
… where it metalates cuproenzymes such as the lysyl oxidase (LOX) family and tyrosinase. Under elevated Cu conditions, ATP7A undergoes Cu-stimulated trafficking to the plasma membrane to export excess Cu into the extracellular space. Studies have shown that many cancer cells exhibit increased …
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Role of peritoneal mesothelial cells and the inflammatory response in peritoneal fibrosis
… adhesion. We first identified that lysyl oxidase (LOX) played a key role in the progression of peritoneal fibrosis by regulating collagen cross-linking and deposition in vivo. The inhibition of LOX enzyme activity prevented the formation of fibrotic tissue by reducing collagen …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… in known aortopathy-related genes. Variants in lysyl oxidase (LOX, 122070160 T>TA), myosin light chain kinase (MYLK, 123401069 ACT>A) and mothers against decapentaplegic homolog 4 (SMAD4, 51076665 C>T) were selected. CRISPR-Cas9 genetic editing introduced these mutations into wild type iPSC …