Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 214 for “"Lysosomes"”.
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Biogenesis of lysosomes in macrophages : intracellular pathway of lysosomal membrane protein to lysosomes
Includes abstract. Includes bibliographical references (leaves 212-248).
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Lysosomes and Ribonucleoprotein Dynamics in Neurons
… better understanding of the unique functions of lysosomes in neurons is necessary. To gain deeper insight into the biochemistry of neuronal lysosomes, we developed methods to engineer and culture human iPSC-derived neurons. Within this system, we used proximity labeling proteomics to profile the …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
… activation of store-operated Ca2+ entry (SOCE). Lysosomes are the core digestive compartments of the cell, but their importance as signalling organelles is also now widely appreciated. Accumulating evidence indicates that lysosomal Ca2+ is important for their physiological functions. Lysosomal …
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The role of lysosomes in radiation induced genomic instability
… thus confirm the suitability of the system. The lysosomes were then analysed for permeability and their distri- bution within the cell. Oxidative stress was also measured in a bid to correlate this event with lysosomal perturbations. Finally lysosomal contents, in particular DNaseIIα, were …
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INVOLVEMENT OF LYSOSOMES IN SPONTANEOUS ATHEROGENESIS AND THE EFFECTS OF ESTROGENS
… prominent features in atherosclerotic lesions. Lysosomes are essential for cellular catabolism and are known to be altered in advanced atheroslcerotic lesions; however, their involvement in spontaneous atherogenesis or lesion progression is unclear. Estrogens have been reported to interact with …
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
… These are targeted for storage in secretory lysosomes and other neutrophil granules for subsequent release by regulated secretion in an inflammatory process. However, the granule content is very potent and may cause tissue damage when released. Basic knowledge about biosynthesis, targeting …
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Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes
… early endosome processing and delivery to the lysosomes. Two models for endosome processing have previously been proposed in the literature, namely the maturation and vesicular traffic models. The general consensus has been an early phase of intermingling of the endocytic contents markers …
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The Hydrophobic Handoff Between NPC2 and the N-Terminal Domain of NPC1 in the Export of Cholesterol from Lysosomes
… lipoprotein is degraded in late endosomes and lysosomes where its cholesterol is released. Egress of cholesterol from late endosomes and lysosomes (hereafter referred to as lysosomes) requires two proteins: Niemann-Pick C2 (NPC2), a soluble protein of 132 amino acids; and NPC1, an intrinsic …
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Characterization of Acid Hydrolases in Normal and Acetate-Deprived Euglena Gracilis and Isolation of Lysosomes From Acetate-Deprived Euglena
Made available in DSpace on 2014-12-11T22:22:12Z (GMT). No. of bitstreams: 1 7121075.pdf: 4993377 bytes, checksum: f8b760b0680d107b16c1e730781f3087 (MD5) Previous issue date: 1971
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Morphological and histochemical observations of hepatic peroxisomes and lysosomes of rats after treatment with methylmercuric chloride, hydrogen peroxide and gamma radiation
… identified hepatic peroxisomes and lysosomes was studied at days 2, 7 and 21 following treatment with hydrogen peroxide (HP), methylmercuric chloride (MMC) and gamma radiation (I). The HP group received five daily intraperitoneal (IP) injections of 1.8 ml of 1.5% HP; the MMC group …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… from the trans-Golgi network (TGN) to secretory lysosomes, followed by generation of membrane-free soluble sTNFR1. The secretion of sTNFR1 could be triggered by a calcium-ionophore or by crosslinking of the IgE receptors on mast cells leading to degranulation. In contrast, sTNFR1-tm-Y-egfp in …
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Lysosomal nutrients and the mTORC1 pathway
… such as cancer. Given the critical role of lysosomes in maintaining cellular homeostasis, a better understanding of lysosomal function and metabolism and its relation to the mTOR pathway is necessary. Most components of the nutrient-sensing machinery upstream of mTORC1 localize to the …
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The Dynamics and Function of the Endolysosomal/Lysosomal System
Lysosomes are intracellular organelles that were considered for a long time to be simply an acidic and hydrolytically active end point of trafficking routes for degradation, in the last 20 years, light has been shed on their functional heterogeneity and striking role in signalling and nutrient …
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New tools for the discovery of pigment gene function
… into melanosomes, and, in non-pigmented cells, lysosomes. Indeed, loss of MFSD12 reduced the accumulation of cystine in lysosomes of fibroblasts from patients with cystinosis, a lysosomal storage disease caused by inactivation of the lysosomal cystine exporter CTNS (Cystinosin). Thus, MFSD12 is …
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Characterization of PCSK9-mediated LDLR Degradation in Hepatic and Fibroblast Cells
… LDLR and directs the receptor for degradation in lysosomes by an unknown mechanism. A gain-of-function mutation, D374Y, increases binding to LDLR EGF-A >10-fold and is associated with a severe form of hypercholesterolemia in humans. Similar to previous studies, data obtained in my project has …
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Studies of intraorganelle dynamics: the lysosome, the pre-lysosomal compartment, and the golgi apparatus
… specific lysosomal membrane antigen, from mouse lysosomes to hamster sucrosomes, sucrose-swollen lysosomes. Lysosomal membrane protein intermixing was also shown by the co-localization of LIMP I, a rat specific lysosomal membrane antigen, and LAMP-1, a mouse specific lysosomal membrane antigen. …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
… of glycolipids and their transportation to lysosomes for degradation and recycling back into the Golgi; however, in the case of LSDs, this is defective. Furthermore, it discusses how impaired endolysosomal acidification and lipid imbalance can be linked and common to LSDs. Chapter 2 depicts …
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Cibler la vulnérabilité lysosomale dans le cancer du rein héréditaire comme nouvelle approche thérapeutique
… mutées en VHL en affectant la fonction des lysosomes de la cellule par l’inhibition de la kinase PIKfyve. Pour ce projet, nous avons émis l’hypothèse que la vulnérabilité lysosomale des cellules mutées en VHL pourrait être exploitée comme approche thérapeutique pour ceux qui sont touchés par …
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Targeting Sequence and Function-Dependence of Subcellular Localization of Transient Receptor Potential Mucolipin Channels and Characterization of Engineered Molecule Probes For Detecting Lysosomal Calcium Release
… TRPML1 is almost extensively localized in lysosomes, TRPML3 is typically found in both lysosomes and the plasma membrane (PM). It has been shown that TRPML3 localization depends on TRPML1, but the mechanism remains unknown. Recently, a number of TRPML1 mutants have been reported to be …
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