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Showing 1 to 1 of 1 for “"Lysosomal exocytosi"”.
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… cells, copper overload triggers autophagy and lysosomal exocytosis via transcription factor EB (TFEB), stimulating copper clearance and reducing toxicity. Lysosomal Ca2+ release through transient receptor potential mucolipin 1 (TRPML1) activates calcineurin, which dephosphorylates TFEB, …