Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Lysosomal clearance"”.
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Regulation of mTORC1 by homocysteine and its effects on autophagy in human and mouse neuronal tissues
… of developing AD. The impact of Hcy on molecular clearance pathways in mammalian cells, including in-vitro cultured induced pluripotent stem cell-derived forebrain neurons and in-vivo neurons in mouse brains is investigated in this research project. Exposure to high Hcy levels results in …
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Challenges in the Pharmacokinetics of Therapeutic Proteins
… and availability in the body. Consequently, clearance through this pathway will reach its maximum and nonlinear pharmacokinetics will be observed upon further increasing dose if TMDD is a major elimination process. This, in turn, will impact the bioavailability estimation. Bioavailability …