Global ETD Search
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Showing 1 to 5 of 5 for “"Lysosomal Ca2+"”.
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
Ca2+ is a universal and versatile intracellular messenger, regulating a vast array of biological processes due to variations in the frequency, amplitude, spatial and temporal dynamics of Ca2+ signals. Increases in cytosolic free Ca2+ concentration ([Ca2+]c) are due to influx from either an infinite …
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TRPML1: Role In Autophagy And Potential Target To Treat Lysosomal Storage Disorders
… control of cell function. Here we show that a lysosomal Ca2+ signaling mechanism controls the activities of the phosphatase calcineurin and of its substrate TFEB, a master transcriptional regulator of lysosomal biogenesis and autophagy. Lysosomal Ca2+ release via mucolipin 1 (TRPML1) activates …
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… cells, copper overload triggers autophagy and lysosomal exocytosis via transcription factor EB (TFEB), stimulating copper clearance and reducing toxicity. Lysosomal Ca2+ release through transient receptor potential mucolipin 1 (TRPML1) activates calcineurin, which dephosphorylates TFEB, …
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The physiological role of P2X4 receptors in lysosome function
… activated by ATP and with a high permeability to Ca2+. They are predominantly localised to lysosomes and from there can traffic to the cell surface. ATP levels within the lysosome are high but P2X4Rs are inhibited by the acidic pH. Previously, it was shown that the alkalinisation of lysosomes …
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GIMAP5 influence la survie des cellules T naïves en participant à la régulation du calcium emmagasiné dans les organites
… de GIMAP5 entraîne une diminution du flux de Ca2+ ainsi qu’une réduction de la capacité mitochondriale à emmagasiner du Ca2+ suite à la stimulation du TCR. Cependant, GIMAP5 n'est pas une protéine mitochondriale. Afin de mieux comprendre le rôle de GIMAP5 dans la biologie des cellules T, au …