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Showing 1 to 20 of 22 for “"Lysophosphatidic acid"”.
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
<p>The simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The …
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Oncogenic Signaling Pathways Activated by Lysophosphatidic Acid (LPA) in Ovarian Carcinoma
… cancer pathogenesis remain poorly defined. Lysophosphatidic acid (LPA) has emerged as a biomarker present in the ascitic fluid and serum of ovarian cancer patients. Subsequent studies have identified LPA as an agonist for G protein coupled receptors (GPCRs). LPA has been well characterized …
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The Design and Synthesis of Autotaxin Inhibitors and Analogs of Lysophosphatidic Acid
<p>Lysophosphatidic acid (LPA) is a naturally occurring bioactive phospholipid. It has a wide array of biological effects like cell proliferation, survival, migration, apoptosis invasion, wound healing and angiogenesis. Autotaxin (ATX) was identified as an autocrine tumor cell motility factor from …
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Reactive Oxygen Species are Second Messengers in the Lysophosphatidic Acid Induced Survival Signaling of Ovarian Cancer
… nature of ovarian cancer is the activity of lysophosphatidic acid (LPA), a constitutively produced lipid mediator that is a potent agonist of signaling cascades that promote tumor growth and survival, including the PI3K/ Akt, MAPK/ ERK, and NF-κB pathways. We found that these signaling …
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Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers
… constants comparable to those of arylboronic acids. Interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of …
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Characterization of novel immunomodulatory proteins encoded by parapoxvirus ORF virus
… of p38 signaling, ORFV113 interacted with Lysophosphatidic acid receptor 1 (LPA1), a G protein coupled receptor. ORFV113 enhancement of p38 activation was prevented by treatment of cell cultures with LPA1 inhibitor, and in LPA1 siRNA and CRISPR knock down cells. Additionally, treatment of …
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Role of the LPA2 Receptor in Protecting Against Apoptosis
<p>Lysophosphatidic acid (LPA) is a naturally occurring lipid mediator. It exists abundantly in biological fluids such as serum, saliva, follicular fluid, seminal fluid and malignant effusions and induces a vast array of biological responses affecting cell growth, survival, differentiation, …
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The Biochemical Pathway Leading to Lpa Generation Upon Blood Coagulation
… activation initiates an upsurge in 18:2 and 20:4 lysophosphatidic acid (LPA) production. The biochemical pathway responsible for LPA production during blood clotting is not fully understood. We have purified a phospholipase A<sub>1</sub> (PLA<sub>1</sub>) from thrombin-activated human platelets …
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Uniaxial Mechanical Assays on Adherent Living Single Cells : Animal Embryonic Fibroblasts and Human Pancreas Cancer Cells
… such as sphingosylphosphorylcholine and lysophosphatidic acid modulated the cytoskeleton architecture which showed to cause fatal consequences for mechanical properties of rat embryonic fibroblasts and human pancreatic cancer cells. Cellular stiffening or softening, power generation and …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
<p>Lysophosphatidic acid (LPA) and its ether analog alkyl glycerophosphate (AGP) elicit arterial wall remodeling when applied intralumenally into the uninjured carotid artery. LPA is the ligand of eight GPCRs and the peroxisome proliferator-activated receptor γ (PPARγ). We pursued a gene knockout …
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The impact of whey protein isolate on energy balance regulation
… length. The functionality of protein sensing lysophosphatidic acid receptor 5 (LPA5) in 3T3-L1 pre-adipocytes was assessed. Over-expression of the receptor in 3T3-L1 pre-adipocytes provided a growth advantage to the cells and suppressed cellular differentiation into mature fat cells. In …
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Biochemical characterization of the first step in ether lipid biosynthesis: acylation of dihydroxyacetone phosphate
… involves acylation of glycerol-3-phosphate to lysophosphatidic acid. GPATs 1 and 2 localize to the mitochondria while GPATs 3 and 4 localize to the ER. This redundancy is poorly understood. A fifth acyltransferase, DHAPAT, known to metabolize dihydroxyacetone phosphate, resides in peroxisomes. …
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
… data presented in this dissertation suggest that lysophosphatidic acid (LPA), via production from ATX’s well characterized lysophospholipase D (lysoPLD) domain, can induce the expression of myelin basic protein (mbp) and the establishment of membranous structures by differentiating …
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The Role of Autotaxin in Cancer
… that converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA is the agonist for at least six G protein coupled receptors whose activation stimulates cell proliferation, survival and migration. Overexpression of ATX and increased levels of LPA have been linked to fibrotic and …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
Lysophosphatidic acid (LPA), a naturally-occurring, simple phospholipid, is present at elevated levels in the blood and ascites of ovarian cancer patients. LPA is a ligand of seven cell surface G protein-coupled receptors. It has been known as an oncogenic growth factor in ovarian cancer and other …
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Diabetic macular oedema: the role of steroids and VEGF
… vascular endothelial growth factor but not lysophosphatidic acid induced permeability suggesting that steroids are able to counteract the effects of certain but all vasoactive compounds. Overall our results suggested that steroids and VEGF lead to opposing effects on microvascular …
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CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS
<p>Lysophosphatidic acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. …
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The development of small molecule inhibitors for fibrosis drug discovery
… lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signalling pathway is implicated in cell survival, migration, and proliferation; thus, the inhibition of ATX is a recognised therapeutic target for a number of diseases including fibrotic …
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… (LTs), lysophosphatidyl choline (LPC), lysophosphatidic acid (LPA) and/or prostaglandins (PGs). TGF$\alpha$ stimulated PG secretion in a concentration-dependent manner. This stimulation was suppressed concentration-dependently by hydroxyurea (1.5-6 mM). TGF$\alpha$-induced DNA synthesis …
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