Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Lysine methyltransferase"”.
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… these challenges by identifying histone lysine methyltransferase (KMT) NSD3 as a critical oncogenic driver of PanNETs through di-methylation of histone H3K36 (H3K36me2).</p> <p>The findings shown in this body of work indicate that H3K36 methylation by NSD3 functions as a transcriptional …
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Release of Histone Lysine Methyltransferases from Rat Brain Chromatin by Nuclease Digestion
<p>The histone lysine methyltransferases catalyze the transfer of methyl groups from S-adenosyl-L-methionine to specific ε-N-lysyl residues in the N-terminal regions of histones H3 and H4. These enzymes are located exclusively within the nucleus and are firmly bound to chromatin. The …
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ROLE OF G9A IN SKELETAL MYOGENESIS
… dysfunction. Here, we provide evidence that the lysine methyltransferase G9a represses expression of several sarcomeric genes, whereby over-expression of G9a disrupts sarcomere integrity of skeletal muscle cells. This inhibition is mediated by G9a catalyzation of repressive histone methylation …
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Functional analysis of Smyd1 and Myomesin in sarcomere organization in zebrafish embryos
… proteins and molecular chaperones. Smyd1 is a lysine methyltransferase that plays important roles in myofibrillogenesis in both skeletal and cardiac muscles. Knockdown of smyd1 results in complete disruption of sarcomere organization. The molecular mechanism by which Smyd1 controls myofibril …
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A C. elegans histone methyltransferase promotes spermatocyte gene expression, spermatid production and fertility
… defined the tissue-specific expression of all 36 lysine methyltransferase (KMT) genes by endogenous mRNA detection in C. elegans. We found that most KMTs are expressed in only one or two tissues and that the germline is the tissue with the most general KMT expression. We discovered that the …
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Impact of Neurodevelopmental Disorder-Associated Clinical Variants on the Catalytic Activity of KMT5B
KMT5B is a lysine methyltransferase that is known for its role in catalyzing H4K20 dimethylation. This post-translational modification is involved in DNA repair and heterochromatin formation. Missense variants found in KMT5B cause a related neurodevelopmental disorder in which patients experience …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
… relapse. Leukemias with rearrangement of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted therapies for <em>KMT2Ar</em> leukemia such as menin inhibitors, …
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Fbxw7 Triggers Degradation Of Kmt2d To Favor Growth Of Mature B-Type Malignant Cells
… first time that FBXW7 is an E3 ligase for the lysine methyltransferase KMT2D. We show that FBXW7 utilizes its conserved WD40 domain to interact with KMT2D. KMT2D contains a stretch of N-terminal phosphodegron repeats that mediate interaction with FBXW7. These phosphodegrons are phosphorylated …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… featuring SETDB1 (SET domain bifurcated histone lysine methyltransferase 1), the heterochromatin protein 1 (HP1) protein family, and the nucleosome remodelling and deacetylase (NuRD) complex. Although many protein partners involved in silencing have been identified, the molecular basis of the …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… catalyzed by a family of nine protein arginine methyltransferases (PRMT1-9), which are of three types (I, II, and III). The majority of Type I enzymes asymmetrically dimethylate Glycine- and Arginine-rich (GAR) motifs, except for PRMT4, which methylates Proline-, Glycine-, and Methionine-rich …
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Role of ORCA and ORC in chromatin organization and DNA replication
… repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs). ORC along with the pre-RC protein Origin Recognition Complex-Associated (ORCA/LRWD1), preferentially localizes to heterochromatic regions in post-replicated cells. The role of ORCA …
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Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… </p> <p>Primarily identified as a histone lysine methyltransferase, SMYD2 has been shown to be play important roles in muscle development and tumorigenesis. In addition to histone substrate, SMYD2 can also methylate non-histone proteins including p53, retinoblastoma tumor suppressor and …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… indirectly, drives the expression of an RNA methyltransferase, N6-adenosine-methyltransferase 70 kDa subunit (METTL3). This enzyme catalyses N6-methyladenosine (m6A), the most abundant mRNA modification, through a complex with METTL14 and WTAP. Whilst METTL3 has been described as both an …