Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Lysine Methyltransferases"”.
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Release of Histone Lysine Methyltransferases from Rat Brain Chromatin by Nuclease Digestion
<p>The histone lysine methyltransferases catalyze the transfer of methyl groups from S-adenosyl-L-methionine to specific ε-N-lysyl residues in the N-terminal regions of histones H3 and H4. These enzymes are located exclusively within the nucleus and are firmly bound to chromatin. The …
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The Role of METTL21A in Kras-driven Cancers
<h2>Abstract</h2> <p>More than 100 lysine methyltransferases (KMTs) were predicted to be present in the human proteome, and many were implicated in cancer etiology. However, the catalytic activity and substrate specificity for many of these enzymes remain unknown. Our work aimed to explore the role …
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Role of ORCA and ORC in chromatin organization and DNA replication
… repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs). ORC along with the pre-RC protein Origin Recognition Complex-Associated (ORCA/LRWD1), preferentially localizes to heterochromatic regions in post-replicated cells. The role of ORCA …
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Impact of Neurodevelopmental Disorder-Associated Clinical Variants on the Catalytic Activity of KMT5B
KMT5B is a lysine methyltransferase that is known for its role in catalyzing H4K20 dimethylation. This post-translational modification is involved in DNA repair and heterochromatin formation. Missense variants found in KMT5B cause a related neurodevelopmental disorder in which patients experience …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… RNA (lncRNA) expression and histone tail lysine methylation marks – epigenetic marks with central roles in transcriptional regulation in many biological systems. I examined how these changes correlate with alterations in the CM transcriptome during disease and ageing. Understanding how …