Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Lysine Methylation"”.
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DNA enzymes for peptide-nucleic acid conjugation and for lysine methylation
… 4 describes the efforts toward DNA-catalyzed lysine (Lys) methylation. Lys methylation is an important protein post-translational modification. Developing DNA enzymes to site-specifically methylate Lys side chains on protein surfaces is valuable for biochemical studies. SAM analogs with …
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An investigation into the significance of histone methylation in various mouse tissue
Histone lysine methylation is a post synthetic modification that occurs on the N-terminal tails of histones H3 and H4. This modification occurs at very specific residues, which have been highly conserved throughout evolution. It has been postulated that histone methylation may be involved in the …
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Impact of Neurodevelopmental Disorder-Associated Clinical Variants on the Catalytic Activity of KMT5B
KMT5B is a lysine methyltransferase that is known for its role in catalyzing H4K20 dimethylation. This post-translational modification is involved in DNA repair and heterochromatin formation. Missense variants found in KMT5B cause a related neurodevelopmental disorder in which patients experience …
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Histone modification and the epigenetics of X chromosome inactivation
… of hypoacetylation and patterns of histone methylation in silent chromatin. Xi was shown to be depleted for di- and tri-methylated lysine 4 of H3, but retained di-methylated lysine 9 of H3. I have examined the temporal order of these modifications as they become established using an in vitro …
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Studies on the Histone Methyltransferase G9a
… Among the known modifications of histones, lysine methylation has been proposed to represent a relatively stable mark which might mediate stable activation or repression, depending upon the site modified. The immune system provides an ideal system in which to test the physiological functions …
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Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… </p> <p>Primarily identified as a histone lysine methyltransferase, SMYD2 has been shown to be play important roles in muscle development and tumorigenesis. In addition to histone substrate, SMYD2 can also methylate non-histone proteins including p53, retinoblastoma tumor suppressor and …
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Plant Homeodomain Finger Protein 20 (Phf20) and Its Homolog Phf20 Like 1 (Phf20L1) Define Two Distinct Non-Specific Lethal (Nsl) Complexes
… Lethal (NSL) complex, which acetylates lysine residues on histone H4 and regulates gene expression. The current model assumes that PHF20 and PHF20L1 are present together in the NSL complex, although it has never been tested. Performing extensive biochemical analysis, we observed that …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… RNA (lncRNA) expression and histone tail lysine methylation marks – epigenetic marks with central roles in transcriptional regulation in many biological systems. I examined how these changes correlate with alterations in the CM transcriptome during disease and ageing. Understanding how …
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Histone H3 K4 Methylation Regulates The Spindle Assembly Checkpoint Through Direct Binding of Multiple Checkpoint Components and Cdc20
<p>Histone H3K4 methylation is conserved across species and is associated with active transcription. By using <em>Saccharomyces cerevisiae</em>, we found histone H3K4 methylation has a previously unknown role in regulating mitosis through the Spindle Assembly Checkpoint. The Spindle Assembly …