Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 178 for “"Lyn"”.
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Protein Tyrosine Phosphorylation in Haematopoietic Cancers and the Functional Significance of Phospho- Lyn SH2 Domain
… in cancer-derived cell lines. Using the Lyn SH2 domain as a model, I discovered that when this tyrosine (Y194) is phosphorylated, the domain has reduced ability to interact in vitro with phosphopeptides and phosphoproteins. Sequence analysis of the binding motifs revealed that …
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
… is linked with over-expression and activation of Lyn, a member of the Src family kinases (SFK). The main aim of the project was to investigate whether transforming growth factor-β (TGF) might influence drug-resistance through direct affects on Lyn kinase levels and its activation. This research …
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Writing on the margins : the experimental poetry of Lyn Hejinian, Yang Lian and Arkadii Dragomoshchenko
… situation, poetry and artistic intentions of Lyn Hejinian, Yang Lian 楊煉 and Arkadii Dragomoshchenko, three experimental poets whose work pushed the boundaries of poetry within their respective countries, the United States, China and the Soviet Union, from the late 1970s to the early 1990s. …
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The Novel Role of Hematopoietic Lyn Substrate-1 Associated Protein X-1 in Cardiac Contractility and Cardioprotection
<p>Hematopoietic cell-specific Lyn substrate associated protein-1 (HAX-1) was discovered in 1997 and suggested to play an anti-apoptotic role in B-cells. Although HAX-1 is ubiquitously expressed in all tissues, its role in the heart remains virtually unknown. Interestingly, recent studies …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… production of autoantibodies. Mice deficient in Lyn, a gene associated with human lupus, develop several features characteristic of SLE, including peripheral plasma cell accumulation, anti-dsDNA antibodies, and GN. Lyn is a Src-family tyrosine kinase that, in general, inhibits B cell and myeloid …
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… interaction between the src tyrosine kinase, Lyn, and the Ets family transcription factor, Ets1, in autoimmunity. Lyn is both a positive and negative regulator of BCR signaling; however its net effect is inhibitory. Lyn deficiency results in hyperactive B cells and Lyn-/- mice serve as a …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… partners. These included SLP-76, Vav1, and Lyn, and we found that this complex was interrupted by inhibiting Lyn. Lyn inhibition also blocked ATRA- and CD38-stimulated phosphorylation of c-Cbl and p85 PI3K, suggesting some aspects of CD38 signaling are dependent on Lyn kinase activity. …
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Assessment of the effects of impingement and entrainment on the fish community of the New River, Virginia
… effects of operation of the intake of the Glen Lyn Power Station on the fish community of the New River, Glen Lyn, Virginia. Estimates of the numbers of fishes impinged by the Glen Lyn Power Station were made for the period mid-May 1976 through May 1977. The estimated total impingement was 6219 …
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
… mediated by non-receptor tyrosine kinase Lyn that is essential for localized integrin activation, leading edge attachment, and persistent migration during neutrophil chemotaxis. This pathway depends upon Gi protein-mediated activation and leading edge recruitment of Lyn. We documented the …
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Molecular Mechanisms Underlying Differential Regulation of Platelet Dense Granule Secretion by Protein Kinase C delta
… phosphorylation was delayed, occurring at 1 min. Lyn and SHIP-1, but not SHIP-2 or Shc, preferentially associated with PKCδ upon stimulation of platelets with a GPVI agonists, but not with a PAR agonist. In PKCδ null murine platelets, convulxin-induced SHIP-1 phosphorylation was inhibited, …
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The role of mechanical loading in chondrocyte signaling pathways
… loading, we used lipid raft-targeting (Lyn-FAK and Lyn-Src) and non-lipid raft-targeting (KRas-FAK and KRas-Src) biosensors. We also developed a three-dimensional (3D) cell culture system using collagen-coupled agarose gels to mimic the physiologically relevant cell microenvironment. The …
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Rolle der Src-Kinasen in den Signaltransduktionswegen von Interleukin-6 und Erythropoetin
… Darüber hinaus scheint die Src-Kinase Lyn eine Rolle in der erythrozytären Differenzierung zu spielen.
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CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… whose anti-tumour effects function through Lyn kinase, a member of the Src family kinases. This current study characterised a novel immunomodulatory role for CHL-4, which is able to increase gene and protein expression of Type I/III IFNs in TNBC cell lines. This signalling is dependent on …
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Identification of novel biomarkers for clinical prognosis in breast cancer
… factors e.g. c-RAF-1, ERK-1/2, AKT, LYN, SRC family kinases (SFKs) and NFκB (p50 RelA) were analysed in combination with SK1 and S1P receptors to discover novel prognostic interactions that drive cancer progression in ERα positive breast cancer patients. High tumour SK1 expression in …
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The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins
… both BCR-proximal <br>protein tyrosine kinases, Lyn and Syk. The phosphorylation of SHIP by Syk, but not that by <br>Lyn, was strictly dependent on the presence of an integer BCR complex, indicating that Syk <br>requires BCR expression for the phosphorylation of SHIP. Furthermore, the absence of …
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Cark
… It analyzes the work of poets Tomaz Salamun and Lyn Hejinian, in relation to theorists Theodor Adorno and Maurice Merleau-Ponty, to articulate a poetics specific to the poems in the collection. The poetics is described via the literary and anthropological uses of metaphor, which are employed to …
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Thermal pollution modeling of the New River
Thermal plume data from the Glen Lyn, Virginia power plant on the New River was compared to the thermal plume data from a hydraulic river model of this section of river. Both summer (high temperature, low river flow) and winter (low temperature, high river flow) conditions were modeled. The model …
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
… and directly activating the Src-family kinase Lyn. Chicken thrombocytes are potently activated by collagen but do not form 3-dimensional aggregates under arterial flow conditions, a profound contrast to platelet function. Despite selective expression of most platelet-specific genes, …
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