Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Lymphoproliferative"”.
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TREATMENT AND MODELING OF EPSTEIN-BARR VIRUS POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER
… nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorder (PTLD). In all of these diseases, the expression of Epstein-Barr virus nuclear antigen 1 (EBNA-1) is common and therefore this viral protein represents a possible therapeutic target. Previous studies have intimated that …
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Investigating lesions of Langerhans cells and their role in Lymphoproliferative diseases
Langerhan’s cells (LCs) are the immune sentinels of the skin, sampling the cutaneous microenvironment and presenting captured antigen to T cells. A sheet-like proliferation of LCs is termed Langerhan’s cell histiocytosis (LCH), an enigmatic and poorly understood disorder with a widely varied …
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Immunophenotypic characterization of lymphoid tissue and lymphoproliferative disease in ferrets (Mustela putorious furo)
Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1997.
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Post transplant lymphoproliferative disoders in liver transplant recipients : cases at Red Cross Children's Hospital Cape Town
… 2 deaths), EBV-related post-transplantation lymphoproliferative disease (6 patients, 4 deaths) and CMV disease (9 patients, 4 deaths).
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Novel approaches to assess cellular interactions and their role in the pathology and treatment of lymphoproliferative disorders
Background: Migration and homing are essential to B-lymphocyte mediated immunity, and are driven by rapid, directed, and appropriate reorganisation of the actin cytoskeleton. Important observations have linked the cytoskeletal-rearrangements made by leukaemic B-lymphocytes of chronic lymphocytic …
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Effects of the Removal of Adherent and Phagocytic Cells on the Spleen Cell Lymphoproliferative Response of Tumor Bearing Mice
… with phytohemagglutinin as the mitogen. This lymphoproliferative response was quantitated using the Stimulation Index (SI). Spleen cells from mice injected with #51 cells, a chemically-transformed colon cell line, produced a SI value equal to that of normal mice. There was no evidence for …
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A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disorders
… centres (GC). SHM has therefore been reported in lymphoproliferative disorders (LPDs) from GC origin. Strong prognostic links and clinical indications based on SHM status have been described in chronic lymphocytic leukaemia (CLL) were patients with mutated Ig present improved prognosis and longer …
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The Function of LAT in T Cell Activation and Autoimmunity
… binding site (Y136) of LAT develop a severe lymphoproliferative syndrome. These mice have defective thymic development and selection and lack natural regulatory T cells, implicating a breakdown of both central and peripheral tolerance. The phenotype observed in LAT-/- mice is even more …
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Pten Signaling in Regulatory T Cells and Inflammatory Disease
… and spontaneous development of autoimmune and lymphoproliferative disease in vivo. Interestingly, the exaggerated TFH and GC responses and autoimmune symptoms are suppressed when IFN-γ expression is abrogated in mice containing Pten-deficient Treg cells. Thus, the uncontrolled TH1-mediated …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… weight and reduced viability due to an apparent lymphoproliferative disorder. In a C57BL/6 background, Ariadne 2 deficiency leads to a fully penetrate embryonic lethality, occurring after embryonic day 16.5. Arih2-/- foetal liver have reduced cellularity and increased apoptosis, however …
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ΒΛΕΝΝΟΓΟΝΙΚΑ ΛΕΜΦΩΜΑΤΑ. ΜΕΙΖΟΝΕΣ ΛΕΜΦΟΥΠΕΡΠΛΑΣΤΙΚΕΣ ΑΛΛΟΙΩΣΕΙΣ ΤΟΥ ΣΤΟΜΑΧΟΥ ΑΠΟ ΜΟΡΦΟΛΟΓΙΚΗ ΚΥΡΙΩΣ ΑΠΟΨΗ. ΝΕΩΤΕΡΕΣ ΑΝΤΙΛΗΨΕΙΣ
… (14 OUT OF 24 MAJOR NONLYMPHOMATOUS, LYMPHOPROLIFERATIVE LESIONS) OF THE STOMACH WERE STUDIED. KIEL CLASSIFICATION WAS USED IN THE LYMPHOMAS' STUDY. LYMPHOMAS OF THE STOMACH WERE CONSIDERED AS PART OF THE ENTITY OF MUCOSAL LYMPHOMAS. THE HIGH GRADE OF MALIGNANCY LYMPHOMAS CONSTITUTED …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… sarcoma. It is also associated with the B cell lymphoproliferative disorders, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine …
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CLINICAL AND LABORATORY CHARACTERISATION OF ACQUIRED VON WILLEBRAND SYNDROME
… It is associated with systemic diseases such as lymphoproliferative (LPDs) and myeloproliferative neoplasms (MPNs), cardiovascular, and autoimmune conditions. The underlying biological processes differ across clinical contexts and remain incompletely defined, complicating both diagnosis and …
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Untersuchungen zur Signaltransduktion des CXCR4 (CD 184) Chemokinrezeptors im Hinblick auf Vitalität und Migration humaner B-CLL-Zellen
… Lymphatische Leukämie (B-CLL) ist eine lymphoproliferative Erkrankung, bei der es charakteristischerweise zu einer Akkumulation von langlebigen CD5+, CD19+, CD23+ B-Lymphozyten im Blut, im sekundären lymphatischen Gewebe und im Knochenmark kommt. Akzessorische Zellen im Knochenmark und …
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Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
… and assessing minimal residual disease in lymphoproliferative disorders of dogs, are presented. The results of those molecular assay may be directly translated in the field of Veterinary practice as well as the may be used to improve our objective evaluation of new investigational drugs …
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Defining How Polymorphisms at the Slam Family Locus Affect NK and T Cell Function
… systemic lupus erythematosus (SLE) and X-linked lymphoproliferative disease (XLP). The antinuclear autoantibody (ANA) causative locus, Sle1b, in the NZM2410 mouse model of lupus has been shown to contain the entire SLAM family (SF) locus. Whereas, XLP is caused by mutations in a critical adaptor …
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The Effect of Modeled Microgravity and Radiation on Epstein-Barr Virus in a Modeled Spaceflight System
… nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorder, among others. EBV is known to reactivate during spaceflight, increasing to levels ten times those observed pre-and post-flight. Although stress has been shown to increase reactivation of EBV, other factors, including …
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