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Showing 1 to 20 of 109 for “"Lymphomas"”.
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Translational regulation in aggressive B-cell lymphomas
… a risk of malignant transformation. Aggressive lymphomas arising from the GC stage of B-cell development are the most common haematological malignancies with heterogeneous molecular mechanisms and clinical presentation. Although the last decade witnessed considerable advances in the biology of …
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Biomarker identification in HIV and non-HIV related lymphomas
DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low …
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Revealing the role of Gα13 in germinal centre lymphomas
… is recurrently inactivated in aggressive B cell lymphomas. Furthermore, loss of function mutations in the upstream receptors, *P2RY8* and *S1PR2*, and downstream effectors, *ARHGEF1* and *RHOA*, are also reported in these diseases. Taken together, this pathway is inactivated in over 40% of …
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
We examined the regulation of NFATc1 in different lymphomas and observed an inversed correlation between the methylation status and expression of NFATc1. Our data demonstrate that aberrant DNA methylation associated with chromatin remodeling within nfatc1 locus is a major mechanism for the …
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The Role of Nucleolin In B-Cell Lymphomas and Fas-Mediated Apoptotic Signaling
… the expression of nucleolin in human B-cell lymphomas. We observed that nucleolin is overexpressed in multiple B-cell lymphomas and its localization changes in transformed cells. In a tissue microarray analysis we showed that although total nucleolin levels did not correlate with patient …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
Primary thyroid lymphomas are commonly derived from a background of Hashimoto’s thyroiditis and comprise largely of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) and diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma (FL). The Du group has …
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Contributions of viral and cellular gene products to the pathogenesis and prognosis of aggressive lymphomas
High grade aggressive lymphomas have high mortality. By their nature, more than 40% of patients die from these diseases even with the improved treatment strategies currently available for oncology patients. The characteristic feature is that they are functionally heterogeneous and therefore have …
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Molecular characterisation of Diffuse large B-cell lymphomas (DLBCL) diagnosed at Groote Schuur Hospital (GSH)
… (NOS). Double-hit (DHL) or triple-hit (THL) lymphomas typically have a worse prognosis and outcome compared to DLBCL, NOS. Fluorescence in-situ hybridisation (FISH) is the gold standard cytogenetic method for detecting specific genetic alterations (rearrangement, gain, amplification, and …
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
… B cell patient tumors from several types of lymphomas overexpressing AID, were found to accumulate genomic uracils at levels comparable to those seen in activated UNG-/- B cells. These lymphoma/leukemia cells are not defective in uracil removal and express UNG2 gene at the same level in …
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Investigation of the relevance of DNA ploidy and proliferative fraction analysis in the subclassification of follicular lymphomas
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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ΒΛΕΝΝΟΓΟΝΙΚΑ ΛΕΜΦΩΜΑΤΑ. ΜΕΙΖΟΝΕΣ ΛΕΜΦΟΥΠΕΡΠΛΑΣΤΙΚΕΣ ΑΛΛΟΙΩΣΕΙΣ ΤΟΥ ΣΤΟΜΑΧΟΥ ΑΠΟ ΜΟΡΦΟΛΟΓΙΚΗ ΚΥΡΙΩΣ ΑΠΟΨΗ. ΝΕΩΤΕΡΕΣ ΑΝΤΙΛΗΨΕΙΣ
A SERIES OF LYMPHOMAS (47 CASES) AND PSEUDOLYMPHOMAS (14 OUT OF 24 MAJOR NONLYMPHOMATOUS, LYMPHOPROLIFERATIVE LESIONS) OF THE STOMACH WERE STUDIED. KIEL CLASSIFICATION WAS USED IN THE LYMPHOMAS' STUDY. LYMPHOMAS OF THE STOMACH WERE CONSIDERED AS PART OF THE ENTITY OF MUCOSAL LYMPHOMAS. THE HIGH …
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Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers
… out on the same sections. Intermediate grade lymphomas were the largest category (49.5%), with 16.5%high grade lymphomas. More than half (53.3%) of the lymphomas were of 8 cell immuno phenotype, and 36.5% were T cell lymphomas. Only 9.7% of the total number of lymphomas exhibited double …
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“Watch and Wait” - Examining the potential impact of uncertainty in illness on the mental health of individuals with Chronic Lymphocytic Leukemia and Low Grade Lymphomas
… (CLL) and non-localised low grade or indolent lymphomas (LGL) are two of the common cancers that individuals are diagnosed with in the UK. Both of these chronic illnesses are considered slow growing and these individuals are often diagnosed when one is not exhibiting any symptoms from the …
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… to be localized in several subsets of T-cell lymphomas. However, their localization in cutaneous T-cell lymphomas has been rarely described. In this study, the clinical features, histopathological morphology, and expression of TFH markers in cutaneous T-cell lymphomas were investigated. …
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Profilo molecolare dei linfomi post-trapianto
… They included 50 cases of diffuse large B-cell lymphomas (DLBCL) and 2 Burkitt lymphomas (BL). In order to evaluate the immune-profile a large panel of antibodies was applied including several new markers (Cyclin D2, Cyclin D3, p27, PKC-β, FOXP-1 and Survivin) identified as negative prognostic …
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ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)
… IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE …
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Molecular Pathogenesis of MALT lymphoma
… activate the NF-κB pathway. Gastric MALT lymphomas harbouring such translocation do not respond to Helicobacter pylori eradication, while those without translocation can be cured by antibiotics. To understand the molecular mechanism of MALT lymphoma with and without chromosome …
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