Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Lymphocytes T"”.
-
La redistribution de l'acide arachidonique dans les glycérophospholipides des lymphocytes T humains
… l'effet de l'induction de la prolifération des lymphocytes T primaires sur la distribution et la composition molaire des AG dans chaque classe et sous-classe de GPL. Le deuxième objectif est de comparer certains de ces changements avec la lignée lymphocytaire Jurkat et avec les lymphocytes T …
-
Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
… evaluate T-cell and B-cell responses (in healthy lymphocytes) to GAG treatment and to compare them to control cancer cell lines (MOLT-4, K562 and U698). Methods: Phase 1 of the research isolated GAGs from cockles and whelks. Peripheral blood mononuclear cells (PBMCs) were extracted in bulk from …
-
GIMAP5 influence la survie des cellules T naïves en participant à la régulation du calcium emmagasiné dans les organites
… 5» (Gimap5) ce qui entraine l’apoptose des lymphocytes T. Le mécanisme par lequel la déficience de la protéine GIMAP5 conduit les cellules T à la mort est actuellement méconnu. GIMAP5 a également été associée à différentes maladies auto-immunes, ce qui suggère son influence dans …
-
Étude de la réponse immune lymphocytaire T CD8[indice supérieur +] suite à une infection par un virus Influenza pandémique
… dans les poumons. Trois fois moins de lymphocytes T CD8[indice supérieur +] activés et spécifiques au virus ont été retrouvés dans les poumons des souris infectées avec MAp2009 comparativement au virus conventionnel à jour 8 p.i. De plus, les cellules dendritiques inflammatoires (iDCs) …
-
MODELING, ANALYSIS, AND CONTROL OF SYK-MEDIATED SIGNALING EVENTS FOR B CELLS AND ASSOCIATED CELLULAR RESPONSE FOR B CELLS
… of neutrophils, antigen-presenting cells, and lymphocytes (T cells and B cells), among other cells. Intercellular communication is the means by which immune cells develop coordinated response while intracellular signals determine responses within a cell; both depend on systems of chemical …
-
La communication cryptocrine intrathymique et la tolérance immunitaire centrale au soi neuroendocrine
… dans les sélections positive et négative des lymphocytes T.
-
Gingival MSCs Improve Bone Phenotype in Ovariectomy-Induced Osteoporosis via Programmed Cell Death Pathway
… host, leading to the elevation of T-regulatory lymphocytes (T-regs) and the downregulation of T helper type 1 lymphocytes (Th1) levels in recipient OVX mice. Mechanistically, PD-1/PD-L1 is a popular cellular death pathway being heavily investigated in multiple research fields, In our study, we …
-
Characterization of Vaccinia Virus-Induced Cytotoxic Cells in the Syrian Hamster
… 100 percent thymocytes, 60-80 percent spleen lymphocytes, and less than 10 percent bone marrow cells. Noninduced natural cytotoxic cells and in vivo vaccinia-induced cytotoxic cells were compared to in vitro-generated cytotoxic effector cells with regard to the Thy 1.2 marker. While spleen …
-
The Functions of Autophagy Genes in Lymphocytes and Osteoclasts
… mice lacking essential autophagy genes in B lymphocytes, T lymphocytes, and osteoclasts. We found that the essential autophagy gene <italic>Atg5</italic> was important for B cell development and for the maintenance of B-1a B cell numbers but not peripheral B-2 B cell numbers. In T cells, …
-
Comparison of Two Techniques for Enumeration of Human B and T Lymphocytes
<p>The assay of Bursa-derived and Thymus-derived lymphocytes (B and T cells) in man has become increasingly useful during the past few years in normal and in clinical conditions. There has been quite a range reported in the literature in the percent of B and T cells in normal subjects by different …
-
B and T Lymphocytes in Human Pregnancy
… this purported depression was due to fewer T-lymphocytes or a dysfunction of these cells. T cells were measured by the rosette technique using neuraminidase treated sheep red blood cells (SRBC). B cells were measured using a SRBC-hemolysin-guinea pig complement indicator system. The total …
-
Adoptive cell therapy using primary T lymphocytes with genetically engineered T cell receptors against melanoma and glioma
… therapy with adoptive cell transfer (ACT) of T lymphocytes. T cell immunotherapy is highly attractive because T cells have the ability to selectively recognize and destroy malignant neoplastic cells. Although a promising approach, one of the limitations encountered clinically is the difficulty …
-
Altérations fonctionnelles des cellules dendritiques dans la cancérisation du col utérin
… sont capables d’induire la différenciation des lymphocytes T CD4+ naïfs en cellules T régulatrices (Treg) grâce à l’expression d’ICOSL. Les cellules Treg et les pDC forment des clusters autour des cellules cancéreuses, ce qui facilite leurs interactions. Nous avons identifié HMGB1 comme étant la …
-
L' inhibition de SCD-1 chez la lignée leucémique Jurkat et les cellules T et caractérisation de l'expression des isoformes de la 5-Lipozygenase dans la polyarthrite rhumatoïde et les leucémies
… notamment les lymphomes, les leucémies et les lymphocytes T primaires. Ainsi dans le premier projet de thèse, nous nous sommes intéressés à l'effet de l'inhibition pharmacologique de la SCD-1 non seulement dans la lignée de cellules leucémiques Jurkat mais également sur les cellules T du …
-
Le Rôle de la stéaroyl-CoA désaturase-1 dans le maintien de la prolifération des cellules T et de la lignée leucémique Jurkat
"Dans notre laboratoire on s'intéresse à l'étude du rôle de la SCD-1 dans la prolifération cellulaire. Dans cette étude, nous avons étudié le rôle de la SCD-1 dans la lignée cellulaire leucémique Jurkat et dans les cellules T du sang périphérique. L'effet de l'inhibition de la SCD-1 …
-
Characterizing the roles of gut microbiota, probiotic Lactobacilli and CX3CR1 in the development of autoimmunity in MRL/lpr mice
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with no known cure. The crosstalk between the gut microbiota and the immune system plays an important role in the tolerance induction to self-antigens both in the intestinal mucosa and at the systemic level. The MRL/lpr mouse …
-
Tumor-induced immunosuppression: Contribution of a high molecular weight inhibitor and Prostaglandin E2
A heat-stable soluble inhibitor of T cell proliferation was demonstrated in splenic and peritoneal macrophage (Mφ) culture supernatants. Concentrated supernatants were prostaglandin E₂ (PGE₂)-free and yet inhibited proliferation in the mixed lymphocyte reaction (MLR) and mitogen assays. The high mw …
-
The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
T lymphocytes are critical components of an effective adaptive immune response, with different subsets performing proinflammatory and immuno-suppressive roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. …