Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Lymphocyte subsets"”.
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Macrophage regulation of T lymphocyte subsets in normal and tumor- bearing hosts
The mixed lymphocyte reaction (MLR) was used to examine the blastogenic response of normal and tumor-bearing host (TBH) murine T lymphocyte subpopulations in the presence of normal and TBH macrophage (MΦ)-derived factors. Rapidly proliferating normal and TBH Lyt-1⁺ T cells were inhibited by high …
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Effects of Acute Nutritional Deprivation on Lymphocyte Subsets and Membrane Function in Cats
… deprivation and subsequent refeeding on lymphocyte functions and subpopulations were examined in 23 healthy cats. Peripheral blood samples were analyzed at various times during fasting and refeeding periods. During the fasting period, decreases were observed in leukocyte number (day 4; p …
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The Effect of Walnuts Compared to Fatty Fish on Plasma and Erythrocyte Fatty Acid Composition, Lymphocyte Subsets and Inflammatory Mediators
… fish on circulating inflammatory markers, on lymphocyte subsets, on plasma concentrations of eicosanoids precursor polyunsaturated fatty acid and on erythrocyte membrane fatty acid composition. Under controlled metabolic feeding conditions and randomized crossover (3x3 Latin-square) design, 27 …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… and immunological assays to characterise lymphocyte subsets in a group of 18 A-T patients and analysed the sensitivity of A-T lymphoblastoid cell lines to CD95-mediated apoptosis. I also investigated the potential role for ATM in immune surveillance via DNA damage-induced upregulation of …
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Bi-directional tumour-host interaction in a murine model
… response profiles were defined in terms of lymphocyte proliferation, cytotoxic function and lymphocyte subsets in naive non-tumour bearing mice and mice with increasing tumour burden. The effect of this antitumour immune response on the developing tumour was examined in a model of mixed …
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Acute Effects of Whole-Body Proton Irradiation on the Immune System of the C57BL/6 Mouse
… whole-body irradiation (WBI) on leukocytes, lymphocytes, and hematological parameters in the spleen and blood of C57BI/6 mice were examined and compared to the effects of photon (gamma) WBI derived from a 60cobalt (60Co) source. Adult, female C57BL/6 mice were exposed to a single dose (3 Gy, …
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Characterisation of physiological and immune-related biomarkers of weaning stress in beef cattle
… neutrophil number) and lymphopenia (decrease in lymphocyte number), reduced interferon-γ production, and increased concentrations of acute phase proteins were evident post weaning, whereas post-housing, changes were less marked. Weaning caused neutrophilia and impaired the functionality of these …
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Environmental signals that control T lymphocytes in the gastrointestinal tract
… Deletion of the AHR results in a loss of key lymphocyte subsets in the barrier organs of the skin and the intestine, but whether these effects are solely mediated by AHR–ARNT complexes is unclear. Moreover, the influence of HIF-1α-ARNT complexes in mucosal lymphocytes has yet to be addressed. …
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Effects of a Simulated Tennis Match on Lymphocyte Subset Measurements
… on cells of the immune system. Specifically, lymphocyte count increases during exercise and decreases to a value lower than baseline following an acute exhaustive bout of exercise. The overall lymphocyte response is well characterized, however, the ability of exercise to affect lymphocyte …
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Mathematical modeling of infectious disease
… immune system using mathematical models of lymphocyte differentiation, expansion, and contraction to memory. These models are fitted to a broad range of experimental data and provide a number of insights into T cell and NK cell behavior. Firstly, the results show that a mechanism of …
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Equine Protozoal Myeloencephalitis. Preliminary Investigation of Protozoan-Host interactions in the horse
… of the CSF fraction, and a decrease in lymphocyte proliferation was not caused by increased cellular death. This suggests the presence of subsets within the CSF which have a stimulatory of suppressive influence on the cells in culture. The effect was cell donor dependant which implies a …
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Role of the colonic lymphoglandular complex in mucosal immunity in swine
… using monoclonal antibodies specific for B and T lymphocyte subsets. Lymphocytes were compartmentalized into B (T-independent) and T-dependent (internodular) areas. CD4[superscript]+ cells were more plentiful than CD8[superscript]+ cells. In nodules, CD4[superscript]+ cells were common but …
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
Pathogenic HIV/SIV infection induces high viral loads, aberrant immune activation, and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… controlled via Akt. When a mature B lymphocyte is stimulated through the BCR, Akt-mediated phosphorylation of Foxos results in their exclusion from the nucleus. In the absence of Foxo nuclear activity, the B cell progresses into the cell cycle. We have discovered a second …
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Development of VHH- and antibody- based imaging and diagnostic tools
… and in vivo characterization of specific immune subsets. We then track their recruitment to sites of active immune responses, such as infection or tumor progression sites. These tools consist of two components: one that confers specificity for immune cells and the other offers a site for labeling …
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Activation of MAIT cells by antigen presenting cells: a comprehensive analysis and assessment of HIV and TB disease on these interactions
MAIT cells are non-classical, innate-like T lymphocyte subsets, which recognize microbial vitamin B metabolites and rapidly respond by producing pro-inflammatory cytokines such as IFN-γ, TNF-α and cytotoxic molecules, which may result in the killing of bacteria-infected cells. Unlike conventional T …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle and are considered essential for endometrial receptivity. The goal of this project was to 1) study the relationship between …
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Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)
… organ to body weight ratios, cell numbers, or lymphocyte subsets. Low dose oral estrogens did not alter the ability of activated splenocytes to induce interferon-γ or nitric oxide. No effects on male reproductive organ to BW ratios of young or aged mice were found. Similarly, with the exception …
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Maternal Modulation of Neonatal Immunity
… maturation of the neonatal immune system.</p> <p>Lymphocytes in blood and spleen were immunophenotyped by flow cytometric analysis to determine differentiation characteristics, and splenocytes were assessed for cytokine production capabilities. In normal Th2-prone outbred (CD-1) mice, an adult …
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Immune biomarkers of clinical outcome in patients with major trauma
… is the role of a subset of CD4+ regulatory T lymphocytes expressing CD25+, CD25Bright, CD127Low and FoxP3+ immune markers, as potential biomarkers for poor clinical outcome following major trauma.We present here data from a prospective observational study of major trauma patients (n=80) …
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