Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Lymphatics"”.
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Intraorgan lymphatics with special reference to the pancreas
… lymph but the pathways by which they enter the lymphatics is unclear. In this study a combined light and electron microscopic technique was utilized along with a morphometric analysis system to investigate the structure and distribution of lymphatic vessels in the head, body and tail portions of …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
… tools to investigate the interplay between lymphatics and their lipid content. We report the first functional measurements of how vessels respond to elevated lipid loads. We further utilized our engineering expertise to develop an experimental platform allowing us to further understand the …
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Utilizing Interactive Imagery To Create A Learning Resource For Students Studying The Lymphatics Of The Head And Neck
… contains pictures of cadavers with overlayed lymphatics on them, specifically the lymph node groups of the head and neck. A software called interactive image was used to place hotspots on these images for the students to click on and receive more information, pictures, or outside links to go …
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Vanishing Act: Lymphatic Vessels and Disappearing Bones
… interest in the development of tissue-specific lymphatics, the cellular origin of bone lymphatic endothelial cells (bLECs) is not known, and the development of bone lymphatics has not been fully characterized. In this dissertation, I review the latest advances in research on the development of …
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The role of lymphatic vessels draining the wall of aorta and coronary arteries in the pathogenesis of atherosclerosis induced by cholesterol/casein diet
… The frequency of plaques without underlying lymphatics was 91.8% and the frequency of lymphatics without overlying plaques was 97.1%. There was an inverse relationship between the area of plaque and the area of associated draining lymphatics in the aortae of the experimental animals. A …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… and glaucoma. Despite the significant roles of lymphatics, its morphogenesis, pathogenesis, and drug delivery strategies are still not completely understood. Organ-on-chip systems combine microfabrication technology with biology, which enables in vitro models to recapitulate key aspects of human …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… metastatic tumour cells, recent reports propose lymphatics as modulators of immunity, highlighting a need for greater understanding of immune regulation by lymphatics. The specific role of lymphatic endothelial cells (LECs) in this context, particularly in TDLNs, is unknown. As TDLNs are immune …
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Engineered models of the lymphatic stroma to study cell and fluid transport
… models of the LN stroma and the meningeal lymphatics to examine the transport of cells and fluid. Within the LN, fibroblastic reticular cells (FRCs) maintain a network of extracellular matrix conduits that guide varying rates of interstitial fluid flow (IFF) based on inflammatory state. …
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Lymphatic pathophysiology of tumors
… paradoxical, as cancer cells do travel through lymphatics in order to disseminate. In order to address some of these issues, this thesis proposes two etiologies for the absence of functional lymphatic vessels in solid tumors. The first hypothesis addresses whether Vascular Endothelial Growth …
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On-Chip Engineered Human Lymphatic Microvasculature for Physio-/Pathological Transport Phenomena Studies
… contain a secondary vascular system known as the lymphatics that supports tissue homeostasis and immune cell trafficking. As such, impairment of the lymphatic capillaries can result in diverse diseases including abnormal tissue swelling (edema), compromised immunity and cancer metastasis. Current …
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Genetic and mechanistic determinants of prostate cancer progression and metastasis
… involved with tumor cell intravasation into lymphatics. The results from this work have shown that loss of Protein 4.1B, a 4.1/ezrin/radixin/moesin (FERM) domain-containing cytoskeletal protein, is a frequent event in prostate cancer. The significance of this finding was confirmed by …
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Utilising zebrafish as a model to investigate lymphangiogenesis and its contributions to disease
… lymphatic networks in zebrafish: the facial lymphatics, the lateral lymphatics, and the intestinal lymphatics. Detailed characterisation of facial lymphatic development revealed that this lymphatic network develops using a novel mechanism, which involves vessel growth through a single …
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The functional and remodeling response of collecting lymphatic vessels to disruption of lymphatic drainage pathways
… is present in most soft tissues of the body. The lymphatics play a vital role in maintaining tissue fluid homeostasis, trafficking immune cells from the periphery to the nodes, and transporting dietary lipids from the intestines to the blood stream. Unlike the blood vasculature, the lymphatic …
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Engineering more potent vaccines for the treatment of cancer and autoimmunity
… 2) be appropriately bulky to drain into the lymphatics, and 3) be rapidly cleared once in the blood to prevent tolerization at distal poorly inflamed organs.
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
… and to maintain fluid homeostasis. Dysregulated lymphatics can be attributed to pathological conditions including tumor metastasis, inflammation, chronic wounds, obesity, blood vascular disorders, and lymphedema. Of these, lymphedema is the most extreme of lymphatic disorders and is represented …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… fluid homeostasis and absorption of dietary fat. Lymphatics also function in the inflammatory response and are involved in pathological conditions such as wound healing and cancer. We show that the Notch signaling pathway is a regulator of both developmental and pathological lymphangiogenesis. …
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CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM
The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and …
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The intraorgan lymphatic system of the rat left ventricle in normalcy and aging
… epicardial and myocardial areas. No endocardial lymphatics were found. Both intercellular and transendothelial visible macromolecular transport pathways were examined in 3, 6, 12, 18, and 28 month old animals. No age-related variations were seen in measurements of intercellular transport …
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… also controlled the vascularization behaviors of lymphatics by modulating the intrinsic composition of the extracellular matrix. Finally, we explored the influence of mechanical stimuli, more specifically interstitial flow, on the formation of lymphatic sprouts to which we observe a dependency on …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… the conjunctival and choroidal blood vessels and lymphatics, thus overcoming the dynamic barrier. A design of experiments (DOE) with JMP software was performed to optimize the formulation’s size, drug loading, entrapment efficiency, critical micellar concentration (CMC), polydispersity index …
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