Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Lymphatic vessel"”.
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Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis
… as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its …
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
… investigated pathological factors based on the lymphatic vessel system and ultrasound features associated with tumor with cervical LNM. Among patients who had undergone thyroidectomy confirmed to be papillary thyroid carcinoma, we selected 126 age-sex matched paired patients without cervical LNM …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic …
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Regulation of VEGFR-3 expression and lymphangiogenesis in normal and inflamed tissues
… primary mediator of lymphangiogenesis (i.e., new lymphatic vessel formation), is frequently associated with inflammation related to chronic disease and cancer. In the latter case, VEGFR-3 dependent lymphangiogenesis induced by inflamed tumors increases the incidence of distant metastasis, leading …
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Minimally invasive assessment of lymphatic pumping pressure using near infrared imaging
Although the major functions of the lymphatic system are fairly well defined, its vasculature has yet to be well characterized in comparison to its blood vasculature counterpart. Recent advances in optical imaging techniques have allowed for more detailed and quantitative evaluations of lymph flow …
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Computational Investigation of Lymphatic Valves and Vessels
The lymphatic system transports macromolecules and fluids throughout the body via contractions of lymphatic vessels. This flow from vessel contractions is regulated by unidirectional lymphatic valves, which allow lymphatic pumping against adverse pressure gradient. Despite the importance of the …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
The lymphatic system is a network consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid …
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Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
The lymphatic system plays a vital role in controlling immune response. Despite this, cancer often reshapes the lymphatic microenvironment and metastasizes into lymph nodes. Theranostic (therapeutic + diagnostic) nanoparticles have been used in a variety of applications, including the detection and …
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An investigation of how dendritic cell migration is modulated during Leishmania mexicana infection
… migration of dendritic cells (DCs) towards the lymphatic vessel network and CCL19-producing lymph node is a key step in the induction of adaptive immunity. Consequently, manipulation of chemokines and chemokine receptors presents a potential mechanism by which parasites can evade protective host …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
The lymphatic system has fundamental physiological roles in maintaining fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. …
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Utilising zebrafish as a model to investigate lymphangiogenesis and its contributions to disease
Lymphatic vessels play an important role in the regulation of tissue fluid homeostasis, immune surveillance and dietary fat absorption. In addition, aberrant lymphatic development is associated with tumour metastasis and forms of chronic inflammation such as inflammatory bowel disease (IBD). …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
… among groups within the germinal center and lymphatic vessel of the lymph node. These results suggest CCR7, CCL28, their receptor and ligands are related to BD symptom patterns in our mouse model.
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Engineered models of the lymphatic stroma to study cell and fluid transport
The lymphatic system plays essential roles in regulating fluid balance and immunosurveillance. Across the body, local lymphatic vessels collect waste in the form of lymph and deliver it to nearby lymph nodes (LNs) to be filtered and screened for pathogens. With broad implications in adaptive …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
The lymphatic vasculature, an essential component of the cardiovascular system, serves several functions critical to embryonic development and adult homeostasis. Lymphatic vessels return interstitial protein-rich fluid to the bloodstream, transport immune cells during immune surveillance and …