Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Lymphatic system"”.
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The membrane, interstitium, lymphatic system : a model of lung water dynamics
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology Program in Medical Engineering and Medical Physics, 1984.
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CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM
The role of the lymphatics as a mode of tumor cell transport has been known for some time, and remains of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and …
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The intraorgan lymphatic system of the rat left ventricle in normalcy and aging
Intracardiac lymphatic vessels of the rat heart left ventricle were studied quantitatively at the ultrastructural level in order to establish baseline morphometric data and also to assess age-related variability in the accepted visible macromolecular transport pathways. Lymphatic vessels were found …
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The history of the development of our knowledge regarding the structure and functions of the lymphatic system
… of the many different parts belonging to the lymphatic system from the beginning of our knowledge of them up to the present day. The object in taking the different parts separately has been to show the progress more clearly and also to impress upon one the great change which takes place when …
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Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles
… possess multiple pathogen recognition systems, and store large quantities of fully active inflammatory mediators. These key features make them uniquely situated to act as sentinels of immunity, releasing the very earliest alarm signals when a pathogen is present. As a testament to the …
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Computational Investigation of Lymphatic Valves and Vessels
The lymphatic system transports macromolecules and fluids throughout the body via contractions of lymphatic vessels. This flow from vessel contractions is regulated by unidirectional lymphatic valves, which allow lymphatic pumping against adverse pressure gradient. Despite the importance of the …
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Pathological study of the pathways of infection to the intracranial structures from foci of inflammation on the face and in the nasal and nasal accessory cavities
… the peripheral focus to within the cranium, the lymphatic system either was stated to be the route or it was suggested that this was the path involved. Equally remarkable was it that in the numerous cases which had been studied up to that time, no attempt had been made to demonstrate …
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Vanishing Act: Lymphatic Vessels and Disappearing Bones
Generalized lymphatic anomaly (GLA) and Gorham-Stout disease (GSD) are related diseases of the lymphatic system. Patients with GLA or GSD develop ectopic lymphatic vessels in bone and gradually lose bone. Despite growing interest in the development of tissue-specific lymphatics, the cellular origin …
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Utilizing Interactive Imagery To Create A Learning Resource For Students Studying The Lymphatics Of The Head And Neck
… textbook methods (Stirling, B. V. 2017). The lymphatic system is an integral part of anatomy that is often overlooked when studying cadavers. In professional school, arteries, veins, muscles, and nerves tends to be emphasized before learning the lymphatic system, namely the lymph nodes. For …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
The lymphatic system is a network consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid …
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Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
The lymphatic system plays a vital role in controlling immune response. Despite this, cancer often reshapes the lymphatic microenvironment and metastasizes into lymph nodes. Theranostic (therapeutic + diagnostic) nanoparticles have been used in a variety of applications, including the detection and …
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The functional and remodeling response of collecting lymphatic vessels to disruption of lymphatic drainage pathways
The lymphatic system is composed of a network of vessels, nodes, and accessory organs that is present in most soft tissues of the body. The lymphatics play a vital role in maintaining tissue fluid homeostasis, trafficking immune cells from the periphery to the nodes, and transporting dietary lipids …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
The lymphatic system has fundamental physiological roles in maintaining fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… can occur through the bloodstream or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. Despite its clinical implications, the mechanisms governing lymphatic …
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Living with lymphoedema in Ireland: a mixed methods exploration of patient and service provider perspectives
… by swelling. It results from impairment of the lymphatic system following cancer treatment, congenital malformation or other medical conditions. This study is the first conducted in Ireland to investigate lymphoedema service provision from practitioner and patient perspectives, in addition to …
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Minimally invasive assessment of lymphatic pumping pressure using near infrared imaging
Although the major functions of the lymphatic system are fairly well defined, its vasculature has yet to be well characterized in comparison to its blood vasculature counterpart. Recent advances in optical imaging techniques have allowed for more detailed and quantitative evaluations of lymph flow …
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
… original environment, move through the blood or lymphatic system, and colonize a distant organ. Mena, a member of the Ena/VASP family of proteins, is upregulated in invasive populations of breast cancer cells. The Ena/VASP (enabled/vasodilator-stimulated phosphoprotein) family of proteins …
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MECHANICALLY MEDIATED GROWTH AND REMODELING OF COLLECTING LYMPHATIC VESSELS
Lymphatic dysfunction plays a key role in pathologies such as immune disorders, infection, cancer, obesity, and cardiovascular disease; regarding the latter, lymphatic dysfunction may exacerbate edema in myocardial infarction (MI) and chronic heart failure. Secondary lymphedema is a progressive and …
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Visual Representation and the Body in Early Modern Anatomy
… which use the examples of the rete mirabile, the lymphatic system and the unborn to analyze the different functions of anatomical images and how they were used to deal with uncertainty, establish new anatomical knowledge and reflected changing cultural meanings of the body.
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Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters
… cavity, the nasal vasculature, or the nasal lymphatic system. However, intercellular transport of large volumes of intranasally instilled inoculum between nasal epithelial cells has been recently reported in hamsters. Intercellular transport in the nose could potentially be used for the …
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