Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Lymphatic Vessels"”.
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Vanishing Act: Lymphatic Vessels and Disappearing Bones
Generalized lymphatic anomaly (GLA) and Gorham-Stout disease (GSD) are related diseases of the lymphatic system. Patients with GLA or GSD develop ectopic lymphatic vessels in bone and gradually lose bone. Despite growing interest in the development of tissue-specific lymphatics, the cellular origin …
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Characterization of endothelial cells of lymphatic vessels
… cells form the inner lining of blood and lymphatic vessels. In mice only tumours of the blood vessel endothelium (haemangiomas) have been thus far reported. In the first part of this thesis is described a highly reproducible method for the induction of benign tumours of the lymphatic …
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MECHANICALLY MEDIATED GROWTH AND REMODELING OF COLLECTING LYMPHATIC VESSELS
Lymphatic dysfunction plays a key role in pathologies such as immune disorders, infection, cancer, obesity, and cardiovascular disease; regarding the latter, lymphatic dysfunction may exacerbate edema in myocardial infarction (MI) and chronic heart failure. Secondary lymphedema is a progressive and …
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Effects of ionizing radiation on normal and tumor-associated lymphatic vessels
Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic …
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Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis
… as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its …
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The functional and remodeling response of collecting lymphatic vessels to disruption of lymphatic drainage pathways
The lymphatic system is composed of a network of vessels, nodes, and accessory organs that is present in most soft tissues of the body. The lymphatics play a vital role in maintaining tissue fluid homeostasis, trafficking immune cells from the periphery to the nodes, and transporting dietary lipids …
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The role of lymphatic vessels draining the wall of aorta and coronary arteries in the pathogenesis of atherosclerosis induced by cholesterol/casein diet
It has been suggested that inadequate lymphatic drainage contributes to the pathogenesis of atherosclerosis. However, there are very few reports to support this hypothesis. This work was designed to study the role of lymphatic vessels draining the wall of the aorta and coronary arteries in the …
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Lymphatic pathophysiology of tumors
… on cancer survival, but the mechanisms for lymphatic metastasis are not well understood. The universal finding in solid tumors of an absence of functional lymphatic vessels seems paradoxical, as cancer cells do travel through lymphatics in order to disseminate. In order to address some of …
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
The lymphatic vasculature, an essential component of the cardiovascular system, serves several functions critical to embryonic development and adult homeostasis. Lymphatic vessels return interstitial protein-rich fluid to the bloodstream, transport immune cells during immune surveillance and …
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Minimally invasive assessment of lymphatic pumping pressure using near infrared imaging
Although the major functions of the lymphatic system are fairly well defined, its vasculature has yet to be well characterized in comparison to its blood vasculature counterpart. Recent advances in optical imaging techniques have allowed for more detailed and quantitative evaluations of lymph flow …
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VEGFR-3 and Tie pathways in vascular network formation
The blood and lymphatic vascular systems are essential for life, but they may become harnessed for sinister purposes in pathological conditions. For example, tumors learn to grow a network of blood vessels (angiogenesis), securing a source of oxygen and nutrients for sustained growth. On the other …
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Utilising zebrafish as a model to investigate lymphangiogenesis and its contributions to disease
Lymphatic vessels play an important role in the regulation of tissue fluid homeostasis, immune surveillance and dietary fat absorption. In addition, aberrant lymphatic development is associated with tumour metastasis and forms of chronic inflammation such as inflammatory bowel disease (IBD). …
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The intraorgan lymphatic system of the rat left ventricle in normalcy and aging
Intracardiac lymphatic vessels of the rat heart left ventricle were studied quantitatively at the ultrastructural level in order to establish baseline morphometric data and also to assess age-related variability in the accepted visible macromolecular transport pathways. Lymphatic vessels were found …
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New Aspects of Alveolar Adaptive Immune Responses in COPD
… revealed an intricate connection between LAs and lymphatic vessels. Further, a marked increase in the number of alveolar lymphatic vessels was detected in patients with advanced COPD. Importantly, in COPD lymphatic vessels had an activated phenotype as revealed by increased lymphatic expression of …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
The lymphatic system has fundamental physiological roles in maintaining fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
The lymphatic system is a network consisting of lymphatic vessels and lymphoid organs such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid …
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Clearance systems at brain borders
… of Doctor of Philosophy in Neuroscience. The glymphatic movement of fluid through the brain powerfully clears metabolic waste. We observed multisensory 40 Hz stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
The lymphatic vascular system is necessary for physiological regulation of tissue fluid homeostasis and absorption of dietary fat. Lymphatics also function in the inflammatory response and are involved in pathological conditions such as wound healing and cancer. We show that the Notch signaling …
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Pathological study of the pathways of infection to the intracranial structures from foci of inflammation on the face and in the nasal and nasal accessory cavities
… the peripheral focus to within the cranium, the lymphatic system either was stated to be the route or it was suggested that this was the path involved. Equally remarkable was it that in the numerous cases which had been studied up to that time, no attempt had been made to demonstrate …
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Genetic and mechanistic determinants of prostate cancer progression and metastasis
… involved with tumor cell intravasation into lymphatics. The results from this work have shown that loss of Protein 4.1B, a 4.1/ezrin/radixin/moesin (FERM) domain-containing cytoskeletal protein, is a frequent event in prostate cancer. The significance of this finding was confirmed by …
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