Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Lymphangiogenesis"”.
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… regulator of both developmental and pathological lymphangiogenesis. Notch1 and Notch4 are expressed by the lymphatic endothelium, and Delta-like ligand 4 (Dll4) is the predominantly expressed Notch ligand in the developing lymphatic vessels of the embryonic dermis and pathological lymphatic …
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Regulation of VEGFR-3 expression and lymphangiogenesis in normal and inflamed tissues
Elevation of VEGFR-3, the primary mediator of lymphangiogenesis (i.e., new lymphatic vessel formation), is frequently associated with inflammation related to chronic disease and cancer. In the latter case, VEGFR-3 dependent lymphangiogenesis induced by inflamed tumors increases the incidence of …
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Utilising zebrafish as a model to investigate lymphangiogenesis and its contributions to disease
… visualisation of lymphatic vessel development (lymphangiogenesis). The aim of this work was to investigate the mechanisms of developmental and disease-associated lymphangiogenesis using novel zebrafish lymphatic reporter lines that utilised the promoter of lyve1, a gene previously shown to be …
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Risk of cervical lymph node metastasis in papillary thyroid carcinoma: Correlations with lymphangiogenesis and ultrasound features
… did not show correlations. Intratumoral lymphangiogenesis was most strongly associated with LNM and thus, could be a useful predictive marker for cervical LNM.
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Investigating lymphatic vascular remodelling during postnatal mouse mammary gland morphogenesis.
… growth and development of lymphatic vessels (lymphangiogenesis) is a common feature of human disorders including lymphoedema, inflammatory diseases and tumour metastasis (Alitalo et al., 2005; Tammela and Alitalo, 2010). Lymphatic vessels are of key importance to breast cancer patients. …
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Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis
… molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, our findings elucidate the cellular and …
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Quantitative analysis of neuropilin-2 expression in pigmented lesions and melanoma
… widespread. The processes of angiogenesis and lymphangiogenesis as well as changes in the extracellular environment all play significant roles in the expansion of a primary melanoma and ultimately metastasis. Neuropilins, specifically Neuropilin-2 (NRP2), have been found to be associated with …
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Prediction of nitric oxide concentrations during inflammation and carcinogenesis
… tumor-cell proliferation, angiogenesis, or lymphangiogenesis. However, the concentrations of NO in inflamed tissues or during carcinogenesis are largely unknown. The objective of the research in this thesis was to predict NO concentrations in an inflamed colon and a cutaneous metastatic …
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The effect of brain-specific VEGF-C deletion on vascular morphology in the brain and skull
… growth factor C (VEGF-C) promotes mainly lymphangiogenesis, but it can also stimulate angiogenesis by binding to VEGFR3 and VEGFR2 on endothelial cell surface. We studied VEGF-C expression by β-galactosidase staining in VegfcLacZ/+ mice. This revealed Vegfc expression in various parts of …
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Novel mechanisms for buffering the haemodynamic effects of dietary salt and the relevance of skin sodium in humans
… salt loading results in Na+ accumulation and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C (VEGF-C), both attenuating the rise in BP. This represents an additional system for maintaining BP and volume homeostasis in response to salt load. The focus of this thesis …
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
… key player in progression of many cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a highway for metastatic tumour cells, recent reports propose lymphatics as modulators of immunity, …
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
… impairs the normal wound healing processes of lymphangiogenesis and angiogenesis in mice. These studies suggest that SHIP2 could have a previously unidentified effector role in lymphatic dysfunction.</p> <p>In elucidating the roles of SHIP2 in lymphatic dysfunction, the work presented herein …
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Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
… vasculature benefiting the tumor, through lymphangiogenesis. This dissertation seeks to understand how the mechanisms of commonly used chemotherapeutics, like carboplatin, and a novel 2nd generation ablative therapy called High Frequency Irreversible Electroporation (H-FIRE), which utilizes …
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TLR4 is a novel determinant of the response to paclitaxel in breast cancer
… inflammatory circuits that promote angiogenesis, lymphangiogenesis, and metastasis at both the site of local invasion and the premetastatic niche in distal organs. Therefore, it can be speculated that tumor expression of TLR4 may indicate poor prognosis and response to therapy, and that blocking …
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INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… survival and migration during angiogenesis and lymphangiogenesis. In particular, the αv integrins have key roles in embryonic development of blood vessels in placenta and brain, whereas fibronectin-binding integrins are essential for developmental angiogenesis. In addition, it has been …
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Vorläuferzellen des lymphatischen Endothels
Seit mehr als einhundert Jahren wird der Ursprung des Lymphgefäßsystems kontrovers diskutiert. Die ersten morphologisch erfassbaren Lymphgefäßanlagen bei Vögeln, Säugetieren und dem Menschen sind die sogenannten Lymphsäcke. Die tradierte Lehrmeinung über die Lymphgefäßentwicklung beschreibt die …