Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"Lyme disease"”.
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Development of Oral Vaccines Against Lyme Disease
<p>Lyme Disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. If left untreated, it can lead to permanent damage to the nervous and musculoskeletal systems. In some cases, patients that receive the recommended antibiotic …
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Lyme Disease and Forest Fragmentation in the Peridomestic Environment
Over the last 20 years, Lyme disease has grown to become the most common vector-borne disease affecting Americans. Spread in the eastern U.S. primarily by the bite of Ixodes scapularis, the black-legged tick, the disease affects an estimated 329,000 Americans per year. Originally confined to New …
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The Emergence of Lyme Disease in Appalachia (2000-2019)
Emerging infectious diseases continue to threaten human health and healthcare resources across the world, and with the sustained emergence of some like Lyme disease, this trend is only expected to get worse. Even though some research has examined the spread of Lyme disease in different parts of the …
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Network Analysis to Identify Biological Pathways Associated with Lyme Disease
Lyme disease (LD) was the most common vector-borne pathogen in the United States from 2004-2016 and is mainly caused by the spirochete bacteria Borrelia burgdoferi sensu stricto, spreading through tick bites. It has different symptoms such as neurological issues, inflammation, and arthritis. The …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… uneven number of rRNA genes, a feature unique to Lyme disease Borrelia. Additionally, the 16S and tandem 23S-5S operons appear to be synthesized as two separate transcripts. Our data show that B. burgdorferi RNase III processes the 3´ end of the 16S, 23S, but not the 5S, rRNA transcripts, as in …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… uneven number of rRNA genes, a feature unique to Lyme disease Borrelia. Additionally, the 16S and tandem 23S-5S operons appear to be synthesized as two separate transcripts. Our data show that B. burgdorferi RNase III processes the 3´ end of the 16S, 23S, but not the 5S, rRNA transcripts, as in …
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The Spatial and Molecular Epidemiology of Lyme Disease in Eastern Ontario
Lyme disease is an emerging tick-borne illness in Canada, with human case numbers increasing 15- to 20-fold since Lyme disease became nationally notifiable in 2009 until the present. In Ontario, Canada's largest province by population, average Lyme disease incidence across the province is similar …
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A community modeling approach to understanding the ecology of Lyme disease
… scapularis) is responsible for transmitting the Lyme disease pathogen (Borrelia burgdorferi) to humans in eastern North America. Since the 1970s, the geographic distributions of both the pathogen and the black-legged tick have expanded throughout the US. This expansion is thought to be primarily …
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Modeling the Impact of Projected Land Cover on Lyme Disease Emergence
Lyme disease is a common tick borne disease in the US. Lyme disease emerged from the Northeast and in the past decade, Virginia has been witnessing a rapidly increasing trend in incidence. This thesis uses land cover projection data as a basis to look at the potential future trend of Lyme disease …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… and characterized the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… and characterized the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated …
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Three Papers on Patient Experiences with Symptom Persistent Lyme Disease in Canada
… on patient experiences with symptom persistent Lyme disease in Canada. Lyme disease infection rates are rising across the country, a phenomenon attributed to climate change and the northern migration of ticks. The focus of this dissertation can advance knowledge in this area by addressing a gap …
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Investigation into peptidoglycan biosynthetic enzymes from the Lyme disease spirochete Borrelia burgdorferi
B. burgdorferi, the causative agent of Lyme disease, has unique chemical characteristics within its peptidoglycan (PG), such as the incorporation of L-Ornithine. This unusual structural feature may be implicated in immune evasion and may contribute to chronic symptoms such as Lyme arthritis and …
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Elucidating the role of peptidoglycan from Borrelia burgdorferi in Lyme disease pathogenesis
As of 2024, more than 50,000 people suffer from Lyme arthritis — a debilitating late-stage symptom of Lyme disease. Symptoms remain even after the completion of antibiotic therapy and when there is no longer any indication of an active infection. Studies have found that a portion of the bacterial …
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Lyme disease in Indiana : isolation of Borrelia burgdorferi-like organisms from Dermacentor variabilis
… the etiological agent, Borrelia burgdorferi, of Lyme disease (LD), using dark-field and immunofluorescence microscopy, and tissue samples cultured in BSK II medium for 7 to 21 days. Spirochetes were isolated in the BSK II medium from pools of midgut diverticula from 6 D. variabilis from Martin …
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Trends in Canine Lyme Disease on the Eastern Shore of Virginia, 2000-2005
Introduction: Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi. Research has shown that dogs can be used as sentinels for human infection of Lyme disease. The purpose of this 5-year, retrospective study was to determine if there was any evidence that the incidence of canine …
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A “tick”-Ing Threat: The Surveillance And Ecology Of The Lyme Disease System
Vector-borne diseases (VBDs) are the most common types of emerging infectious diseases in the world and constitute major threats to public health. Understanding the interplay between the environment, vector, and pathogen that expedite disease spread remains a challenge. The overarching goal of this …
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