Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Lyme"”.
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Immune Mediators of Murine Lyme Arthritis
Lyme disease is the most common vector-borne disease in both the United States and Europe; however, its pathogenesis is incompletely understood. The studies described in this thesis aid in the elucidation of mechanisms regulating murine Lyme arthritis and may suggest mechanisms by which human Lyme …
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Development of Oral Vaccines Against Lyme Disease
<p>Lyme Disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. If left untreated, it can lead to permanent damage to the nervous and musculoskeletal systems. In some cases, patients that receive the recommended antibiotic …
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Lyme Disease and Forest Fragmentation in the Peridomestic Environment
Over the last 20 years, Lyme disease has grown to become the most common vector-borne disease affecting Americans. Spread in the eastern U.S. primarily by the bite of Ixodes scapularis, the black-legged tick, the disease affects an estimated 329,000 Americans per year. Originally confined to New …
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The Emergence of Lyme Disease in Appalachia (2000-2019)
… and with the sustained emergence of some like Lyme disease, this trend is only expected to get worse. Even though some research has examined the spread of Lyme disease in different parts of the United States, focusing on its origin, spread, surveillance, and reporting, there has been minimal …
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Network Analysis to Identify Biological Pathways Associated with Lyme Disease
Lyme disease (LD) was the most common vector-borne pathogen in the United States from 2004-2016 and is mainly caused by the spirochete bacteria Borrelia burgdoferi sensu stricto, spreading through tick bites. It has different symptoms such as neurological issues, inflammation, and arthritis. The …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… uneven number of rRNA genes, a feature unique to Lyme disease Borrelia. Additionally, the 16S and tandem 23S-5S operons appear to be synthesized as two separate transcripts. Our data show that B. burgdorferi RNase III processes the 3´ end of the 16S, 23S, but not the 5S, rRNA transcripts, as in …
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Novel Ribosome Biogenesis in the Lyme Disease Spirochete Borrelia burgdorferi
… uneven number of rRNA genes, a feature unique to Lyme disease Borrelia. Additionally, the 16S and tandem 23S-5S operons appear to be synthesized as two separate transcripts. Our data show that B. burgdorferi RNase III processes the 3´ end of the 16S, 23S, but not the 5S, rRNA transcripts, as in …
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The Spatial and Molecular Epidemiology of Lyme Disease in Eastern Ontario
Lyme disease is an emerging tick-borne illness in Canada, with human case numbers increasing 15- to 20-fold since Lyme disease became nationally notifiable in 2009 until the present. In Ontario, Canada's largest province by population, average Lyme disease incidence across the province is similar …
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Mechanisms of inflammation resolution in a murine model of Lyme arthritis
In some patients, Lyme arthritis persists despite antibiotic clearance of Borrelia burgdorferi, indicating an underlying defect in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi infection of C3H/HeJ mice induces a self-limiting arthritis, allowing …
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Developing In Vitro and In Vivo Models for Lyme Neuroborreliosis (LNB)
Lyme neuroborreliosis (LNB) is a neurologic disorder caused by infection with Borrelia burgdorferi, resulting in inflammation in the central and peripheral nervous systems. LNB remains poorly understood due to the lack of a suitable experimental model. The non-human primate model for LNB presents …
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Identifizierung und Charakterisierung neuer Impfstoffkandidaten zum Schutz gegen die Lyme-Borreliose
… Deutschland jährlich 40.000-80.000 Menschen an Lyme-Borreliose. Die Diversität der Erreger erschweren die Diagnose und die Entwicklung eines Impfstoffes. Bislang fehlt ein allgemein akzeptierter Diagnose-Standard, ein Impfstoff für den europäischen Markt, sowie eine therapeutische Vakzine als …
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Next-Generation Sequencing of vlsE Recombinational Switching in the Lyme Spirochete
… burgdorferi and other spirochetes that cause Lyme disease effectively evade the acquired immune response through antigenic variation. The VlsE antigen is expressed on the spirochete surface during mammalian infection. Virtually unlimited numbers of variants are generated through segmental gene …
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A community modeling approach to understanding the ecology of Lyme disease
… scapularis) is responsible for transmitting the Lyme disease pathogen (Borrelia burgdorferi) to humans in eastern North America. Since the 1970s, the geographic distributions of both the pathogen and the black-legged tick have expanded throughout the US. This expansion is thought to be primarily …
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Modeling the Impact of Projected Land Cover on Lyme Disease Emergence
Lyme disease is a common tick borne disease in the US. Lyme disease emerged from the Northeast and in the past decade, Virginia has been witnessing a rapidly increasing trend in incidence. This thesis uses land cover projection data as a basis to look at the potential future trend of Lyme disease …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
… and characterized the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the virulence-associated …
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Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate …
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