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Showing 1 to 20 of 39 for “"Lycopene"”.
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Lycopene metabolism in transgenic mice
… benefits. The non-provitamin A carotenoid, lycopene, has shown to be one of the most abundant carotenoids in serum and is correlated with a wide range of health benefits. Lycopene has been thought to exhibit its bioactivity from its antioxidant structure or its metabolites. However, it …
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Testosterone, Lycopene Isomers, and Prostate Cancer
… study was to determine the influence of purified lycopene, tomato powder, and 20% diet restriction on N-methyl-N-nitrosourea (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex glands. Only tomato …
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Lycopene, Selenium, Vitamin E and Prostate Cancer
Epidemiologic studies suggest that tomato and lycopene consumption and serum lycopene concentrations are inversely related to prostate cancer occurrence. The oldest, and possibly most cited potential mechanism of action, is that lycopene increases gap junction communication by increasing connexin …
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Transcriptomic and proteomic analysis of lycopene-overproducing Escherichia coli strains
… coli recombinantly producing the small molecule lycopene. Global genomic and proteomic expression changes associated with increased lycopene production of mutant E. coli constructs were discovered using whole-genome DNA microarrays and a novel LC-MS technique, respectively. While most genes and …
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Insight Into the Metabolism of Lycopene: Focus on Androgen -Dependent Tissues
This research has shown that lyc metabolites accumulate in the prostate, seminal vesicles and adrenal gland compared to the other analyzed tissues. Moreover, modulated carotenoid cleavage enzyme(s) expression in the adrenal, prostate and kidney suggested that the accumulated lyc metabolites in …
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GENOME EDITING, A NEW BIOTECNOLOGICAL APPROACH TO PRODUCE LYCOPENE-RICH PIGMENTED ORANGES
Il consumo di frutti ricchi in composti antiossidanti è fortemente apprezzato dai consumatori, essendo noti i loro effetti benevoli per la salute umana, grazie alla loro abbondanza in sostanze ad alto valore nutrizionale e nutraceutico. Tuttavia, in natura, non esistono frutti di agrumi ricchi in …
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Destruction of biological tetrapyrrole macrocycles by hypochlorous acid and its scavenging by lycopene
… scavenge HOCl. In this respect, we report that lycopene a common dietary carotenoid displays excellent HOCl scavenging property. Owing to the extensive hyperconjugation in its structure, one molecule of lycopene theoretically has the</p> <p>capability to scavenge 39 molecules of HOCl. Currently …
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Production and utilization of phytoene, phytofluene, and lycopene tracers for bioavailability and biodistribution studies
… bioactive compounds including the carotenoids lycopene (LYC), phytoene (PE), and phytofluene (PF). Much emphasis has been placed on the bioactivity of LYC, but emerging research suggests that the colorless carotenoids, PE and PF, are bioactive and significantly accumulate in human and animal …
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The role of tomato and lycopene consumption on prostate carcinogenesis and prostate cancer treatment
… survival. Tomatoes and their primary bioactive (lycopene) are one of the most researched foods that have the potential to reduce prostate carcinogenesis. Currently, the majority of the literature has been observational epidemiological literature with inconsistent results. Although preventing PCa …
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Tissue lycopene absorption and accumulation in transgenic mice lacking one or both carotenoid cleaving enzymes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability
Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led …
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Genotype effects impact lipids and organ weights in female mice lacking carotenoid cleavage enzymes
… eventually form biologically-active retinoids. Lycopene is a non-provitamin A carotenoid and the most abundant carotenoid in tomatoes. Lycopene is a poor substrate for CMO-I, but our lab along with other has proposed that the enzyme carotenoid 9'10'-monoxygenase (CMO-II) can oxidatively cleave …
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The Influence of Beta-Carotene and Lycopene on Human Prostate Tumor Cells in Vitro and Human Prostate Tumors in Mice
… to investigate the influence of tomatoes, BC and lycopene on prostate carcinogenesis under biologically relevant conditions. To this end, a novel approach for the delivery of carotenoids to cells in culture and a murine model were developed. There was no evidence from the athymic model that whole …
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Carotenoid metabolism in mice and prostate cancer risk
… of tomato products or higher blood levels of lycopene. β-carotene is centrally cleaved by carotene monoxygenase I (CMO-I) to form vitamin A and further metabolism results in formation of retinoic acid and other retinoids. The metabolism of β-carotene has been extensively studied, but very …
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Enrichment of tomatoes and broccoli with specific bioactives for the reduction of prostate carcinogenesis
… 10% standard tomato powder, tomato enriched with lycopene or total carotenoids, standard broccoli floret, broccoli sprouts, or broccoli enriched with indole glucosinolates or selenium for 7 days. All broccoli diets increased activity of colon quinone reductase (NQO1). Indole glucosinolate-enriched …
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Development of systematic and combinatorial approaches for the metabolic engineering of microorganisms
… single and multiple gene knockout targets for lycopene production in E. coli. These targets led to substantial increases in lycopene production, but were limited in scope due to the nature of these models. Therefore, these approaches and targets were complemented with combinatorial searches to …
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Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas
… and IL-6 in tumors. IL-6 was reduced in high lycopene and broccoli, P=0.05, and TNF-alpha was lower with low lycopene, P=0.05. Overall, the combination of tomato and broccoli powders was more effective at slowing tumor growth than either tomato powder or broccoli powder alone.
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Tomato Phytochemicals and Prostate Cancer Risk
… accumulation, such that phytofluene and lycopene had the highest carotenoid accumulation in the liver and prostate, respectively. Provision of a single oral dose of either phytoene or phytofluene resulted in an increase in the dosed carotenoid concentration in most tissues. To evaluate an …
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Reducing the risk of prostate cancer with tomato and soy bioactives
… components, but the tomato carotenoids, lycopene, β-carotene, phytoene, and phytofluene, receive much of the attention regarding PCa incidence. As tomato carotenoids are lipophilic, strategies to enhance absorption and tissue distribution have been of interest. Evidence suggests that …
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Nutritional factors and lifestyle in prostate cancer patients
… A systematic review of the literature related to lycopene intake and prostate cancer progression suggested that evidence available to date was insufficient to draw any firm conclusions regarding the benefits of lycopene supplementation in prostate cancer patients. <br/>4) Preliminary analysis of a …
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