Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Ly6G"”.
-
Aging Exacerbates Neutrophil Pathogenicity In Ischemic Stroke
… administration of the monoclonal antibody anti-Ly6G has been found to specifically and robustly deplete neutrophils in mice. Encouragingly, our early work confirmed that post-stroke anti-Ly6G treatment results in a transient decrease in circulating neutrophils, making it a promising tool for …
-
Corneal Wound Healing: Cells and Molecules
… received an intraperitoneal injection of anti-Ly6G antibody to deplete circulating PMNs while others received topical applications of recombinant interleukin-20 (rIL-20) to blunt inflammation. To determine if platelet extravasation was dependent on CD18 expression levels, two groups of mutant …
-
Intravital Imaging of Dynamic Behaviors of Leukocytes in UVB-induced Skin Inflammation
… UVB treatment. Depletion of neutrophils by anti-Ly6G monoclonal antibody (mAb) administration did not affect LCs migration in response to the same UVB radiation, but rather promoted LC precursors’ repopulation to the epidermis after UVB treatment. In addition, depletion of neutrophils greatly …
-
Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… that IFN-I increased the intratumoral levels of Ly6G cells, CD8 T cells, and NK cells, and that the anti-tumor benefit of IFN-I was dependent on IL-6 signaling and multiple immune cell types. I sought to establish therapeutic synergy between IFN-I therapy and PD-1 pathway checkpoint inhibition, …
-
HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… microenvironment, marked by an accumulation of Ly6G+ granulocytes and F4/80+ macrophages, increased deposition of fibronectin, and upregulation of the IL-6/JAK/STAT3 pathway. Subsequent transcriptomic analysis of STAT3 deficient livers identified hepatocyte-derived acute phase reactants serum …
-
Investigating the efficacy and mechanism of action of mesenchymal stromal cell therapy in burn wound healing
… with increased CD206+ macrophages and reduced Ly6G+ neutrophils present within the wound, but this biology had no effect on re-epithelialisation.
-
The role of superantigens during Staphylococcus aureus nasal colonization and infection
… which resulted in increased trafficking of CD11b+Ly6G+ neutrophils into the liver. Additionally, wild-type infection resulted in higher numbers of hepatic abscesses containing viable bacteria compared to Newman Δsea representing a specialized in vivo niche for S. aureus. Thus, the mechanism of …
-
HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… of CD11b+Ly6C++ inflammatory monocytes and CD11b+Ly6G+ neutrophils. Peritoneal recruitment of these inflammatory monocytes and neutrophils in HDAC6-/- mice was significantly decreased compared to the WT mice. Pristane treatment also induced the interferon (IFN) signature genes as determined by …
-
Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
… breast cancer lung metastasis with an anti-Ly6G neutrophil depleting antibody, Sivelestat (Neutrophil Extracellular Traps inhibitor) and anti-LAG3+anti-CTLA4 immunotherapy regime abrogated the Brd7-KO induced lung metastasis.</p> <p>Taken together, our findings that BRD7 is a suppressor of …
-
TLR4 is a novel determinant of the response to paclitaxel in breast cancer
… generation of myeloid progenitors (i.e. Ly6C and Ly6G) that can promote metastasis by enhancing the formation of tumor blood and lymphatic vessels. There was also an enhancement of blood and lymphatic vessels in HCC1806 (TLR4 over-expressed) tumors on paclitaxel treatment as analyzed by IHC. …