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Showing 1 to 4 of 4 for “"Ly49"”.
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Phänotyp und Funktion KLRG1-exprimierender Lymphozyten der Maus
… (MHC) über inhibitorische Rezeptoren der Ly49-Familie induziert wird, konnten auf klassische Klasse-I-Moleküle und neue Ly49-Familienmitglieder ausgeweitet werden. Ferner belegen Daten dieser Arbeit, dass reife NK-Zellen die KLRG1-Expressionsfrequenz in verschiedenen lymphoiden Organen dem …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
… receptors, which in mice belong to the Ly49 family of receptors. However, many properties of this process remain unclear. To explore potential determinants of NK cell licensing on a single Ly49 receptor, we have investigated the relative licensing impacts of the b, d, k, q, r, and s H2 …
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… are implicated in tumor surveillance. Inhibitory Ly49 receptors determine the specificity of murine NK cells by recognizing of MHC class I molecules expressed on the target cell. This allows the transmission of inhibitory signals through intracellular signals to block NK cytotoxicity. Many tumors …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… been observed in these loci in contrast to the Ly49 and MHC-I loci in mice. Furthermore, through the usage of BWZ reporter cell assays, we reveal several new cognate receptor-ligand pairs in addition to the previously reported NKR-P1B:Clr-b and NKR-P1F: Clr-g interactions; they are: NKR-P1F: …