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Showing 1 to 3 of 3 for “"LuxS Inhibitors"”.
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Biochemical Evaluation of SRH Analogs as Potential LuxS Inhibitors
… facilitated by the autoinducer AI-2. The enzyme LuxS catalyzes the formation of AI-2 from <em>S</em>-ribosyl homocysteine (SRH) in a wide variety of bacterial species. Inhibition of LuxS would therefore inhibit interspecies quorum sensing. The goal of this project is to establish biochemical …
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Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors
… (SRH) by the enzyme LuxS and induces interspecies cell-to-cell communication. Inhibition of LuxS would therefore inhibit interspecies QS. Herein, a search for novel molecular species that will competitively bind with SRH in the LuxS binding site is performed <em>in …
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Synthesis of S-Ribosyl-L-homocysteine and Analogs Modified at the Homocysteine-C3 Position
… options against many bacterial diseases. The LuxS enzyme converts <em>S</em>-ribosyl-L-homocysteine (SRH) into homocysteine (HCys) and 4(<em>S</em>),5-dihydroxypentane-2,3-dione (DPD), which is the precursor of autoinducer-2 (AI-2). Thus, inhibitors of LuxS could prevent QS by halting the …