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Showing 1 to 20 of 21 for “"Luteinizing hormone releasing hormone"”.
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Structure and biological activity of avian hypothalamic luteinizing hormone-releasing hormone
… (Schally et al., 1971) isolated gonadotropin-releasing hormone (now called luteinizing hormone-releasing hormone (LH-RH)) from sheep hypothalami and established that the hormone was a decapeptide with the amino acid sequence: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂. The peptide was …
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Localization of Luteinizing Hormone-Releasing Hormone (LHRH) in the Hypothalamus of Fetal Bovine
Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) are mammalian gonadotropins released from the anterior pituitary by Gonadotropin Releasing Hormone (GnRH) in the hypothalamus. Various analogs ofGnRH have been identified. Localization of these hormones is the first step in discovering …
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Steroid and monoamine dependent modulation of luteinizing hormone releasing hormone in the ovariectomized rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Factors affecting luteinizing hormone releasing hormone and somatostatin release from rat hypothalami in virto
… buffer and factors affecting the release of luteinizing hormone releasing hormone (LHRH) and immunoreactive somatostatin (IRS), investigated. The viability of the tissue was assessed by oxygen consumption and by the rate of protein synthesis. Protein synthesis continued for up to 60 min but …
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Characterization of Luteinizing Hormone - Releasing Hormone (Lhrh) Release From Rat Hypothalamus Using an in Vitro System
… compounds on the release of immunoreactive luteinizing hormone-releasing hormone (LHRH) from rat hypothalamus was examined using an in vitro superfusion system and sensitive assays for LHRH measurement. High extracellular (60 mM) K('+) ion repeatedly stimulated in vitro LHRH release, an …
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Gonadal steroid regulation of luteinizing hormone-releasing hormone and luteinizing hormone release in the male sheep
The purpose of this thesis was to investigate the role of testosterone (T) and its metabolites, estradiol (E) and dihydrotestosterone (DHT) in the regulation of LH release in male sheep. The first four studies examined the ability of T, E or DHT to inhibit LH release, and the sites at which they …
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A Study of the in Vivo Release of Luteinizing Hormone-Releasing Hormone as Estimated With the Push-Pull Perfusion Technique
The in vivo release of luteinizing hormone-releasing hormone (LHRH) from the mediobasal hypothalami (MBH) of unanesthetized rats and sheep was estimated by means of a push-pull perfusion (PPP) system. Ovariectomized (OVx) rats received 5 (mu)g estradiol benzoate at 1000 h, followed 48 h later by …
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The Synthesis and Characterization Of A Functionalized Diethylenetriamine Rhenium Complex Followed By Analytical Analysis of Novel Rhenium-Luteinizing Hormone-Releasing Hormone Conjugates
… (HPLC) was also performed on rhenium-Luteinizing Hormone-Releasing Hormone (LHRH) conjugates. The synthesis and characterization (proton nuclear magnetic resonance (1H-NMR) spectroscopy and mass spectrometry) of this complex, as well as analytical HPLC results will be discussed.</p>
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The hypothalamic-hypophysial-gonadal axis in the freely behaving male rat
It is a generally accepted finding that pulsatile luteinizing hormone (LH) secretion in the male rat is orchestrated by hypothalamic release of luteinizing hormone releasing-hormone (LHRH). A consequence of both its anatomical predicament and its rapid half-life, is that LHRH is largely …
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Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
… system regulating the release of luteinizing hormone releasing hormone (LHRH) has been actively investigated since the classic 1947 work of Sawyer. The literature indicates that LHRH release is primarily under the control of the $\alpha$ adrenergic system. The $\alpha$ adrenergic …
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Progesterone Action on Hypothalamic Lhrh Neurons: In Vitro and In Vivo Studies
… the effect of progesterone (P) on hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons, as estimated by in vitro (superfusion) and in vivo (push-pull perfusion) techniques. The administration of P unequivocally stimulated the release of LHRH from hypothalamic tissue obtained from …
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A Lamprey Gonadotropin-releasing Hormone in the Bovine Brain
… pituitary is under control of the hypothalamic luteinizing hormone-releasing hormone (LHRH) and a putative analog, follicle stimulating hormone-releasing factor (FSHRF). Analogs of mammalian LHRH and their receptors have been isolated in various animals; of these, the …
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The Role of GABA in Reproductive Neuroendocrine Systems
… neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.</p> <p>Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The experiment determined the release of LHRH, …
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Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
… CD13 which binds specifically to NGR peptides. Luteinizing hormone-releasing hormone (LHRH), another targeting moiety, has been found to be more prevalent in tumor cells than normal cells and has receptors. LHRH sequence was used in the synthesis of targeted curcumin, phthalocyanine and platinum …
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Mechanisms controlling in vitro progesterone synthesis by the ovine placenta
… 3’, 5', cyclic adenosine monophosphate (cAMP), luteinizing hormone-releasing hormone (LHRH) or no additional treatment. Progesterone concentration in the medium after incubation were determined by radioimmunoassay. The temporal pattern of in vivo progesterone synthesized during gestation …
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Distribution and biosynthesis of LH-RH and structurally related peptides
… subserve multiple physiological roles. Thus, the releasing factors of the hypothalamus or their structural analogues may carry out multiple endocrine, paracrine, or neurotransmitter functions outside the hypothalamus. This thesis describes the distribution and biosynthesis of Luteinizing …
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Development Of Novel Breast Cancer Chemotherapeutics Directed Towards The Attenuation Of Metastatic And Chemo-Resistant Breast Cancer
… cancer cells. It has been previously found that Luteinizing Hormone Releasing Hormone (LHRH) receptors are overexpressed in many different cancer types, thus giving a new target to deliver higher concentrations of drug while sparing normal tissues. By linking a molecule of this peptide with …
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Controlled cultivation techniques for the recovery of threatened fishes in Virginia
… 1688 I.U./kg and 20 mg/kg, respectively, or with luteinizing hormone releasing hormone analogue (LHRHa) and domperidone at mean dosages of 363 µg/kg and 36 mg/kg, respectively. Most females spawned within 30 h of the first injection. Stripped ova were effectively wet-spawned, and larvae hatched in …
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Structure-activity study of GnRH analogs having conformational constraints
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… embolism and heart attack. At the same time, luteinizing hormone releasing hormone (LHRH) agonists were found to have similar efficacy profile to that of DES but with significantly lower toxicities. Thus LHRH agonists replaced DES. But, there has been a renewed interest in the treatment with …
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