Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Lupus Erythematosus, Systemic"”.
-
Narrowing of the SLES1 Internal Reveals Complex Epistatic Interactions in the Suppression of Autoimmunity
… is a potent susceptibility locus for spontaneous systemic autoimmunity derived from the NZM2410 mouse strain. The NZW-derived suppressive modifier locus, Sles1, specifically prevents the spontaneous loss in tolerance mediated by the B6.Sle1 congenic. Sles1 had previously been fine-mapped to a …
-
Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… to nuclear antigens in the NZM2410 model of systemic lupus erythematosus (SLE). Congenic B6 mice carrying the Sle1b locus produce anti-nuclear autoantibodies (ANAs) but do not develop lupus nephritis as seen in the parental NZM2410 strain. Fine mapping of the Sle1b locus placed it within a …
-
Common Alleles of the SLAM/CD2 Family are Associated with Murine Lupus
… in the NZM2410 model of the autoimmune disease Systemic Lupus Erythematosus (SLE). B6.Sle1b congenic mice produce anti-nuclear autoantibodies (ANAs), and have elevated activated B and CD4+ T cells, and mild splenomegaly. Fine mapping of Sle1b positioned it within a ~900 kb region between 171.3 …
-
The Effects of Pregnancy on Systemic Lupus Erythematosus
<p>The safety of pregancy for the woman with systemic lupus erythematosus (SLE) has long been studied. Controversy exists about the occurrence of exacerbations during pregnancy and the effect these exacerbations will have on the basic disease process. The purpose of this study was to investigate …
-
In Vivo Identification of SLE1B: LY108 Mediates Autoantibody Production
In the NZM2410 model of murine lupus, Sle1b mediates anti-nuclear autoantibody (ANA) production. Our goal is to determine the causative gene in the Sle1b locus. Seven members of the SLAM/CD2 family are located within the Sle1b interval, and previous work has shown that structural and expression …
-
Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
Systemic lupus erythematosus (SLE) is characterized by loss of tolerance to nuclear antigens such as DNA and chromatin, resulting in autoantibody production, immune complex deposition, inflammation, and end organ damage such as glomerulonephritis (GN). Currently, only non-specific, …
-
Hapten inhibition studies assessing the ability of a thymine derived hapten to bind DNA antibodies in sera from patients with systemic lupus erythematosus (SLE)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Molecular Players in Lupus: Leads from Proteomic Screens
Systemic Lupus Erythematosus is a multifactorial systemic autoimmune disorder marked by anti-nuclear antibodies (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive immune tolerance, …
-
Pregnancy and Lupus Nephritis: A Review
The file named "BANSAL-DISSERTATION-2017.pdf" is the primary dissertation file. A supplemental PDF file ("Appendix - Data.pdf") is also available and may be viewed individually.
-
Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nuclear antigens. Hyperactive B cells are present in SLE patients and murine models of lupus, many of which have defects in inhibitors of B cell receptor (BCR) signaling or plasma cell differentiation. …
-
L.E. Factor Test in Acute Disseminated Lupus Erythematosus
Systemic lupus erythematosus is a rare disease. And like other rare diseases it becomes scarcer through lack of consideration. Therefore a high index of suspicion is necessary if the diagnosis is to be made more frequently. Before the discovery of a new diagnostic test, acute disseminated lupus …
-
Immune memory and activation markers in systemic lupus erythematosus
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the loss of tolerance to self-antigens, immune complex deposition, tissue inflammation and destruction. SLE manifestations, prevalence and severity vary among different populations and ethnicities. Even …
-
The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a relapsing-remitting antibody-mediated autoimmune disease characterized by systemic immune complex deposition. A subset of SLE patients has been shown to have elevated CD4+IL-9+ T cells as well as increased secreted IL-9 and Il9 mRNA compared to healthy …
-
Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterised by immune complex deposition and production of autoantibodies against nuclear antigens (ANA). The aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE …
-
Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterised by immune complex deposition and production of autoantibodies against nuclear antigens (ANA). The aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE …
-
The role of clinical, biological, and socioeconomic factors on the development of resilience in women with autorimmune rheumatic diseases : a cross-sectional study
… in those patients with chronic inflammatory systemic diseases. However, the role of clinical, biological and socioeconomic characteristics in autoimmune rheumatic diseases (ARDs) is still unknown. OBJECTIVE To evaluate the association between resilience and socioeconomic, biological and …
-
The role of gut microbiota in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with no known cure. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. Gut microbiota as an environmental factor and the immune …
-
Selective HDAC6 Inhibition in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by abnormalities in multiple components of the immune system resulting in progressive damage to multiple organs. Current treatments for SLE are often intensive and result in side effects and the potential for …
-
The development and validation of a disease-specific instrument to measure quality of life in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. In the evaluation of patients with SLE it is important to measure not only disease activity and damage but also the impact of the disease on their health related quality of life (HRQoL). Disease-specific HRQoL measures are …
-
Studies of Atherosclerosis in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of anti-nuclear autoantibodies, a wide spectrum of clinical signs, and a striking 9:1 female to male disparity in disease incidence attributed to the SLE disease promoting effects of estrogen. …
Page 1 of 2