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Showing 1 to 18 of 18 for “"Lung transplantation"”.
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Fighting time: A qualitative analysis on the impact of lung transplantation in adults with Cystic Fibrosis
During the last decade lung transplantation has become an option for those with end-stage respiratory disease, including Cystic Fibrosis. However, there appears to have been very little written about the experiences of those who are on the lung transplant trajectory. Most of the previous …
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Diagnostic, prognostic and therapeutic considerations in primary pulmonary hypertension
… selection of patients for, and timing of heart-lung transplantation is being considered. I performed a retrospective study on patients with PPH and chronic large vessel thromboembolic pulmonary hypertension (TPH) seen at Groote Schuur Hospital between 1957 and 1985 in an attempt to: 1. Establish …
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Pulmonary Artery and Central Venous Pressures as Prognostic Indicators of Post Lung Transplant Outcome
… (CVP) on poor prognosis in patients undergoing lung transplants has been widely debated. We hypothesized that not only the isolated values of mPAP and CVP, but also the combination of discordant values in these variables may represent an unfavorable condition in lung transplantation. Methods We …
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Tissue repair in lung disorders
The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main …
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Skeletal muscle mitochondrial capacity and metabolism in lung transplant patients and resistance trained subjects
Lung transplant (LTx) recipients have poor exercise tolerance, which persists in spite of the restoration of near normal lung function. This suggests that the exercise limitation is related to defects in skeletal muscle. Firstly, mitochondrial function and metabolism in resting skeletal muscle were …
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Aspects Of Pulmonary Surfactant Metabolism
Pulmonary surfactant stabilizes the lung by reducing the surface tension at the air liquid interface of the alveolus. Phosphatidylcholine represents the principal component of surfactant (70% by weight), other lipids account for 20% of surfactant and the remaining 10% is protein. Four …
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Identification and Analysis of Omentum Derived Suppressor Cells in Regards to Th17 Inhibition
… as a cellular therapy in a mouse allogenic lung transplantation model.</p> <p>Our findings demonstrated activated omentum is mostly comprised of non-hematopoietic cells resembling mesenchymal stem-like cells (MSCs) and myeloid derived suppressor cells (MDSCs). Activated omentum exhibited …
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Examination of ex-vivo lung perfusion in porcine model
Lung transplantation is a lifesaving therapeutic option for a variety of endstage cardiopulmonary conditions. There is a critical mismatch between the availability of suitable lungs and the number of patients awaiting a lung transplant. Ex-vivo lung perfusion (EVLP) is an established technique that …
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Missing Domains Of Lung Transplant Patient Selection
… scientific community in the thirty years since lung transplantation became the procedure of choice for patients with terminal, non-malignant lung disease. Background: Though there is a consensus regarding disease-specific indications for a lung transplant, ambiguity remains regarding how …
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The role of early management and hormone replacement therapy in potential heart and lung donors
Heart and lung transplantation activity is frustrated by the lack of availability of donor organs. The haemodynamic, hormonal and inflammatory changes that follow brain stem death leads to donor organ injury. Appropriate donor management is essential to avoid further damage to already injured donor …
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Bone Health Outcomes in Post-Lung Transplant Patients with Cystic Fibrosis
… in patients with cystic fibrosis (CF). Although lung transplantation (LTx) improves quality of life of CF patients, there is little research examining long-term bone health outcomes following LTx in these patients. OBJECTIVE: We sought to compare long-term bone health outcomes in LTx patients …
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Precision Diagnostics of Donor Lungs Ex Vivo
Ex vivo lung perfusion (EVLP) is an advanced technology that reconditions donor lungs prior to transplantation. Lung monitoring during EVLP provides isolated lung data without confounding factors from other physiological systems. Herein, we used machine learning modelling to process EVLP diagnostic …
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Lung Progenitor Cell Transplantation for Pulmonary Fibrosis and Ex Vivo Expansion of Patch-Forming EpCAM⁺CD31⁺ Cells
… fibrosis (IPF) and other chronic interstitial lung diseases are characterized by progressive destruction of the alveolar architecture, leading to irreversible respiratory failure. Although recent pharmacologic interventions can slow disease progression, lung transplantation remains the only …
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In Vitro Development of Engineered Lung Tissue
<p>Lung disease is the third most common cause of death in the United States, resulting in 400,000 deaths annually \cite{ALA:08}. For many diseases, lung transplantation is the only definitive treatment, yet only 2700 lung transplants are performed each year, limited primarily by a lack of donor …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
Abstract Long-term outcomes for lung transplantation remain disappointing; as many as 50% of lung transplant recipients develop progressive Bronchiolitis Obliterans Syndrome (BOS) by 5 years after transplant. In the last decade, several experimental and clinical studies have demonstrated that …
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Utilidad de la ecocardiografía de estrés dipiridamol con media reserva de flujo coronario y reserva contráctil en el diagnóstico de enfermedad vascular del injerto en pacientes trasplantados cardiacos
… por la International Society for Heart and Lung Transplantation (ISHLT). La DiSE se realizó utilizando el protocolo de alta dosis, en un plazo máximo de 12 semanas respecto a la coronariografía. La RFC se evaluó mediante imágenes intermitentes tanto del movimiento de la pared del ventrículo …
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Proteomic investigation of the molecular targets of mycophenolic acid in human cells
… acute graft rejection for kidney, liver and lung transplantation. The use of MPA is associated with GI toxicity which is a problem to the patients, and a challenge for clinicians. The present study was undertaken to identify novel molecular targets of MPA using a proteomics approach. Two …