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Showing 1 to 13 of 13 for “"Lung surfactant"”.

  1. Characterization of Lung Surfactant Proteins and Lipid-Protein Complexes

    Shelley, Sue Ann Eckhardt2016

    loyola-thes Repository record

  2. Interaction of Lung Surfactant Lipids with Proteins of the Alveolar Space

    Pagast, Peter2016

    loyola-thes Repository record

  3. Characterization of the dynamic behavior of lung surfactant and its components

    Morris, Jonathan Scott, 1973-Massachusetts Institute of Technology1998

    Lung surfactant is essential to respiratory function. Surfactant dysfunction in adult respiratory distress syndrome (ARDS) is associated with an increase in the minimum surface tension achieved on compression which can result in alveolar collapse and decreased lung compliance. Knowledge of the …

    mit Repository record

  4. Vaping Additives Affect Lateral Organization and Functionality of Lung Surfactant Model Systems

    Van Bavel, NicolasScience2022

    … common symptoms point to dysfunction of the lung surfactant (LS). This is a lipid-protein monofilm situated at the air-water interface in alveolar sacs, which acts to lower surface tension, preventing lung collapse during respiration. Inhaled substances that reach the alveoli will encounter …

    calgary Repository record

  5. Biophysical Characterization of Nanoparticle Interactions with Lung Surfactant Models for Enhanced Pulmonary Drug Delivery

    Lai, PatrickGraduate Studies2017

    … has shown promising results in the treatment of lung disease. The impact of these small sized drug carriers on the lungs is remains unclear. One of the first barriers that nanoparticles will encounter upon inhalation is the lung surfactant that lines each alveolus. This is a single molecule layer …

    calgary Repository record

  6. Nuclear Magnetic Resonance Studies of Model and Biological Membranes

    Bowers, John LelandUniversity of Illinois at Urbana-Champaign2014

    … along with the $\sp $C MASS NMR spectra of lung surfactant and myelin. We also have obtained $\sp2$H, $\sp $C, and $\sp $N NMR spectra of labelled amino acids incorporated into the membrane protein, bacteriorhodopsin, of Halobacterium halobium. Our results indicate that there are at least …

    uiuc Repository record

  7. Molecular modeling and simulations of viruses: structure, dynamics and antibody design

    Goh, Boon ChongUniversity of Illinois at Urbana-Champaign2016

    … infection: innate and adaptive immune systems. Lung surfactant proteins are part of the innate immune system, and they act at the front-end of the host defense. Surfactant proteins A (SP-A) and D (SP-D) protect humans from bacterial infection and influenza A virus, respectively. Using structural …

    uiuc Repository record

  8. Synthetic analogues of protein-lipid complexes

    Punyamoonwongsa, PatcharaAston University2007

    … analogues to lipoprotein assemblies found in lung surfactant. These complexes represent a new bio-mimetic delivery vehicle with applications in the cosmetic and pharmaceutical industries. The primary aim of this study was to develop a better understanding of PSMA-DLPC association by using …

    aston Repository record

  9. Hypercoiling and hydrophobically associating polymers : interfacial synthesis, surface properties and pharmaceutical applications

    Tonge, Stephen R.Aston University1994

    … natural apoproteins, such as those found in lung surfactant or plasma apolipoproteins. Stirred interfacial polymerization was used to synthesize potentially biodegradable aromatic polyamides (Mw of 12,000-26,000) based on L-Iysine, L-Iysine ethyl ester, L-ornithine and DL-diaminopropionic …

    aston Repository record

  10. Cellular interaction with novel biomaterials

    Graham, Christopher D.Aston University1998

    … content and ionic hydrogel matrix. Artificial lung surfactant analogues were found to be non cytotoxic but also decreased cell proliferation when tested at higher concentrations. Poly(lysine ethyl ester adipamide) [PLETESA] had the most favourable response on cell proliferation and commercial …

    aston Repository record

  11. Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis

    Dewan, FaizunnaharThe Graduate School and University Center of The City University of New York2023

    … domain endogenous to humans—the neck region of lung surfactant protein D (SP-Nk). The findings show that U2-Nk forms <em>d-</em>periodic fibrils growing 2-3 µm long, further corroborating the unit-staggered model of fibrillogenesis. The findings additionally elucidate the quintessential, …

    cuny-grad Repository record

  12. Investigations into the immunology, physiology and epidemiology of pertussis

    Thomas, Mark GreensladeResearchSpace@Auckland1994

    … to alveolar atalectasis caused by a defect in lung surfactant synthesis, secretion or function. Paper 9 describes the effects of B. pertussis infection on the ciliary function and electron microscopic appearances of human nasal epithelial cells. These findings are extended by similiar …

    auckland-ms Repository record

  13. Manipulating lipid mesostructure using hard and soft material additives

    Steer, Dylan JUniversity of Illinois at Urbana-Champaign2021

    … lipid components present in healthy and diseased lungs. Mammalian breath relies on large periodic changes in the lung surface area. Lipids are naturally present to reduce the energy required for this motion, however, the efficacy depends on maintaining a healthy composition. Small-angle x-ray …

    uiuc Repository record