Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 1 of 1 for “"Lung selectivity"”.
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… activity manifests most prominently in the lungs, where it drives excessive microvascular leakage and consequently can hamper organ function. Several Tie2-targeted therapeutics have shown promising preclinical efficacy in sepsis mouse models, but their clinical translation faces challenges. …