Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"Lung injury"”.
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Understanding Intercellular Signaling During Lung Injury-Repair
<p>The mammalian lung is a complex system of specialized cell types with precise spatial organization designed to cooperate to perform gas exchange. These cell types together coordinate organ development, homeostasis, and repair after injury through signals either presented or secreted, known as …
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Mechanisms of neutrophil recruitment in septic lung injury
… with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. The aim of thesis was to prevent excessive neutrophil accumulation in lung parenchyma on one hand, and to reinforcement of immune system at later phase of sepsis on …
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Amelioration of oxidative lung injury by antiarrhythmic agents
… NADPH-dependent lipid peroxidation in bovine lung microsomes in a dose dependent manner. Since oxyradicals are implicated in the lipid peroxidation process and antiarrhythmic drugs were found to scavenge/quench reactive oxygen species, we proposed that the membrane Stabilizing effects of …
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
… respiratory distress syndrome (ARDS) is a lung condition caused by uncontrolled lung inflammation with excessive immune cell infiltration, which eventually leads to severe pulmonary edema and poor oxygenation. ARDS affects hundreds of thousands of people a year, particularly those afflicted …
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Effects of taurine and hypotaurine on oxidative lung injury
… studies are based on the premise that pulmonary injury, during periods of hypoxia, ischemia, and reperfusion, may be due to increased production of reactive oxygen species, including the superoxide anion (O₂-), hydroxyl radical (-OH), and hydrogen peroxide (H₂O₂), and on the premise that this …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
… cells (PMNcyto). We found that 50% of PMN in lung microvessels had transitioned to PMN cytoplasts (PMNcyto) within 24h exposure to endotoxemia. Despite being anuclear, PMNcyto displayed characteristics distinct from PMN. They showed rapid velocity compared to PMN and the ability to migrate …
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Ensemble Support Vector Machine Models of Radiation-Induced Lung Injury Risk
… develop a potentially fatal inflammation of the lungs known as radiation pneumonitis: RP). In practice, modeling RP factors is difficult because existing data are under-sampled and imbalanced. Support vector machines: SVMs), a class of statistical learning methods that implicitly maps data into a …
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… environment. These insults can cause acute lung injury (ALI), a syndrome characterized by inflammation, increased permeability, and pulmonary infiltrates. Moderate ALI causes hypoxemia, leading to respiratory failure if left unattended. Patients with severe ALI develop acute respiratory …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… of pulmonary inflammation associated with acute lung injury (ALI) using novel surface modified nanoparticles. ALI is characterized by three main pathological events: I) pulmonary edema, II) excessive pro-inflammatory cytokines and chemokines production from alveolar epithelial and endothelial …
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Understanding mechanisms of, and risk factors for, lung injury in the critically ill
Ventilator-induced lung injury (VILI) can be associated with multiple organ dysfunction, yet the mechanisms underpinning it are unclear. It has been proposed that injurious mechanical ventilation can drive lung and distal organ injury through a process of biotrauma, and this was the focus of my …
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Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury
… reduced the severity of AP and associated lung injury. Present study demonstrated that CP96,345 treatment affected the release of substance P (SP), the expression of neurokinin receptor and tachykinin genes, and the expression of various adhesion molecules, in pancreas and lungs. A similar …
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Incidence and Pathogenesis of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Humans
Acute lung injury (ALI) and it’s more severe form, acute respiratory distress syndrome (ARDS), are conditions characterised by neutrophilic pulmonary inflammation, refractory hypoxaemia and diffuse alveolar damage. This work reports on the first UK based prospective study of the incidence and …
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Role of Covalent Modification of Hyaluronan with Inter-Alpha Inhibitor Heavy Chains During Acute Lung Injury
… playing a critical role in tissue maintenance, injury, and repair. Hyaluronan (also known as hyaluronic acid, HA) is a ubiquitous ECM polysaccharide consisting of a repeating disaccharide backbone that can be covalently modified by the heavy chains (HC) of the serum protein inter-alpha-inhibitor …
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Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury
… burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive oxygen/nitrogen species (ROS/RNS) that in turn drives an inflammatory response and consequently cell …
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THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES
… the static airway properties to determine lung compliance. In addition to using mechanical measurements of lung function, we used a few well-established assays to characterize oxidative stress levels via measurement of glutathione peroxidase activity, nitrosative stress levels by measuring …
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Lung mechanics in the aging lung and in acute lung injury. Studies based on sinusoidal flow modulation.
Knowledge about lung mechanics is of interest in intensive care to adjust mechanical ventilation and in the lung laboratory for diagnostics and evaluation of patients with various kinds of respiratory diseases. In mechanical ventilation a single inspiratory elastic pressure-volume (Pel/V) curve is …
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Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury
… inflammatory event as well as long term tissue injury, scarring and fibrosis. One such pulmonary condition is acute respiratory distress syndrome (ARDS) which, despite decades of intensive research and multiple clinical trials, remains without a cure and has an associated mortality rate of …
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Lung microenvironment plays a key role on the protective vs. detrimental effects of mesenchymal stromal cell therapy in acute lung injury
… for therapy due to their ability to home into injury sites and help in recovery. However, MSC are sensitive to stimulations from their surroundings and some evidence suggests that MSCs can contribute to fibrosis. Thus it is important to understand how MSCs behave in various lung injury …
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
… antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by compound 48/80 has also attenuated acute pancreatitis-associated lung injury and sepsis-associated lung injury by attenuating the levels of chemokines. …
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