Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Lung fibroblasts"”.
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REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS
… characterized by the replacement of functional lung parenchyma with fibrotic tissue. PF develops due to chronic injury to the lungs, and leads to decreased lung compliance, function and a significant reduction in the quality of life for the patient. Currently, there are no treatments available …
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Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts
Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that …
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Studying the Effect of Low Doses of Ionization Radiation on Senescence in Human Lung Fibroblasts.
The exposure to high doses of ionizing radiation (>5Gy) is unequivocally associated with increased cancer risk. However, there is substantial experimental evidence showing that in response to low doses of ionizing radiation (LDR: <100mGy), cells and organisms are benefitted with delayed ageing, …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… cigarette smoke extract induces senescence in lung fibroblasts and alveolar epithelial cells. 1,2,3,4-diexpoxybutane, or diepoxybutane (DEB), is the most reactive metabolite of 1,3-butadiene, an important hazardous air pollutant and potent genotoxic agent found in cigarette smoke. In this study …
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Heavy metal toxicity in human lung fibroblasts and inhibition of human topoisomerase-I as a potential mechanism
… of cadmium, lead, copper and zinc on human lung fibroblasts at physiological levels has been studied. Also, the inhibition of the enzyme Topoisomerase-I, is suggested as a potential mechanism and the purification of the protein was attempted for future work. The present study gives …
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The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
… model using density dependent bovine embryonic lung fibroblast (BELF). The effect of this process on the antioxidant defense enzymes such as, the superoxide dismutases, catalase, glutathione reductase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase, was studied. We have also …
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The role of accelerated ageing in aberrant lung tissue repair and remodelling in COPD
… with characteristic of ageing demonstrated in lungs from COPD patients compared to age-matched smokers without COPD. Recently, extracellular matrix (ECM) dysregulation has been described as an additional ageing hallmark of the lungs. ECM dysregulation can cause aberrant lung tissue repair and …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was determined that NSCLC cell lines (A549, A427, …
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Mycoplasma Pneumoniae Infections - Role of Nucleotide Metabolism in the Mechanism of Pathogenesis
… the mycoplasmas to induce a CPE in MRC-5 human lung fibroblasts, and alterations in the metabolism of the host cells due to mycoplasma infection.
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The Effects of Radon and its Progeny on Human Skin Cells
… due to local geology. Radon is known to cause lung cancer, therefore its potential role in skin carcinogenesis is of interest, as Southwest England also has high skin cancer incidence. A novel radium-226 flow-through apparatus was employed to dissolve radon and its progeny into cell media. …
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The Cytotoxic Effects of Malondialdehyde on Human Lung Fibroblast Cells
… the toxic effects of MDA on the human lung fibroblasts MRC5, which have an intact p53 response, and their SV40 transformed counterpart, MRC5 SV2, which have a sequestered p53 response. Both cell lines were treated with MDA (0-1000 µM) for 24 and 48 h and subjected to a variety of …
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Extended transient transfection by repeated delivery of in vitro-transcribed RNA
… expression was transduced in MRC-5 human fetal-lung fibroblasts by repeated transfection with capped, poly(A)+ ivT RNA encoding a protein with an intracellular half-life of approximately three days. Transfection at 24-hour intervals with ivT RNA encoding a less stable protein resulted in protein …
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The role of microvesicles in EMT and tumour microenvironment
… was examined through use of Non-small lung cancer cells (A549) derived-MVs on primary lung fibroblasts (MRC5). MRC5 cells were treated with A549 cell derived-MV produced significantly high level of myofibroblasts marker alpha-smooth muscle actin (α-SMA) cytoskeleton protein and FGF. MVs …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
… of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced pulmonary fibrosis. Firstly MSC expansion of Treg cells was shown to be dependent on Jagged 1 signalling. MSC inhibition of DC maturation and antigen presentation was shown to also involve Jagged 1 however …
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Materials and biological approach to gene delivery in human embryonic stem cells
… hard-to-transfect cells like IMR-90 human fetal lung fibroblasts and human embryonic stem cells (hESCs). The PEG-b-PVBLG-8 contained a membrane-disruptive, cationic, helical polypeptide block (PVBLG-8) for complexing with DNA and a hydrophilic PEG block to improve the biocompatibility of the gene …
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The role of Biophotons in cellular senescence.
… models: two cancer (MCF7 breast and A549 lung) and two non-cancer cell lines (MCF10A breast and IMR-90 lung fibroblasts). Dox-treated cells showed senescentrelated physiological changes, including decreased proliferation (P ≤ 0.05), increased betagalactosidase activity (P ≤ 0.001), …
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Soy Isoflavones Mediate Radioprotection Of Normal Lung Tissue By Modulating The Radiation-Induced Inflammatory Response
<p>Radiation-induced lung injury (RILI) is caused by an early inflammatory process triggered by damage to lung parenchyma, epithelial cells, vascular endothelial cells and stroma. Initially, oxidative injuries after radiation induce altered expression of pro-inflammatory cytokines. Infiltrating …
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Tumor cell extravasation in an in vitro microvascular network platform
… paracrine non-contact co-culture with human lung fibroblasts yield the most interconnected and stable networks. Vasculatures developed exhibit tight endothelial cell-cell junctions, basement membrane deposition and physiological values of vessel permeability. Employing our assay, we …
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