Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"Lung adenocarcinoma"”.
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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Therapeutic Targeting of Protocadherin 7 in Lung Adenocarcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
Lung cancer is the most prevalent cancer type, leading to more than one million deaths per year worldwide. The vast majority of these mortalities were attributed to metastasis, which is the dissemination of tumor cells from the lungs to other organs. The molecular mechanisms for metastasis is …
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Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
Lung adenocarcinoma (LUAD) remains the world's leading cause of cancer related mortality with an estimated two-hundred thousand new cases arising in 2019 in the United states alone. Molecular characterization of patient tumors has identified activating mutations in the small GTPase, KRAS, …
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Integrated multiparametric deep spatial phenotyping of mouse models of lung adenocarcinoma
… a genetically engineered mouse model (GEMM) of lung adenocarcinoma. I extracted biomarker expression levels and morphological, textural, and spatial motifs of single cells from the imaging data and used these features to train algorithms to predict tumor histologic grade, a measure correlated …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
<p>Lung cancer metastasis is leading the causes of cancer-related mortality in the United States and worldwide. Epithelial-to-mesenchymal transition (EMT) is a model for metastasis that results in loss of specialized epithelial cell contacts and acquisition of mesenchymal invasive capacity. Zinc …
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Applying multi-omics to detect indolent and aggressive early-stage lung adenocarcinoma
Histologic grading of lung adenocarcinoma (LUAD) is a strong predictor of outcome but can only be completed after surgical resection. Biomarkers that are predictive of indolent and aggressive LUAD grade have the potential to improve preoperative management of early-stage disease. Here, we leveraged …
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Fibulin-2 Stabilizes Tumor Extracellular Matrix and Drives Malignant Progression of Lung Adenocarcinoma
… these deficiencies using mouse models of human lung adenocarcinoma. Spontaneous lung tumors were marked by disorganized basement membranes, dense collagen networks, and increased tissue stiffness. Metastasis-prone lung adenocarcinoma cells secreted fibulin-2 (Fbln2), a matrix glycoprotein …
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Genetic differences in lung adenocarcinoma cells from patients of African and European ancestry
… elucidate clinically significant disparities in lung adenocarcinoma (LUAD) genetics across distinct ethnicities, particularly focusing on African ancestry (AA) and European ancestry (EA) populations. A meticulous comparison of genetic traits within LUAD cells derived from these ethnic groups is …
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Roles for the polycomb group protein BMI1 in lung adenocarcinoma progression and maintenance
… I used mouse models of oncogenic Kras driven lung cancer to explore the potential dependence of lung adenocarcinoma, among the deadliest of cancers, on Bmil for tumor initiation, progression, and maintenance. Specifically, I demonstrate that Bmil is dispensable for tumor initiation but …
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Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
<p>Lung cancer is the leading cause of cancer-related deaths in the United States, largely due to its ability to metastasize. Epithelial-to-mesenchymal transition (EMT) is a process that enhances the ability of cells to lose their cell-cell contacts, invade, and enter the blood stream which are …
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Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
… of cutaneous squamous cell carcinoma (cuSCC) and lung adenocarcinoma (LUAC). I have found that TAp63-null (TAp63-/-) mice exhibit increased susceptibility to UVR-induced cuSCC. To identify TAp63-regulated transcriptional programs relevant to the pathophysiology cuSCC, we performed RNA sequencing …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… cancer risk factors such as tobacco smoking. Lung cancer is the leading cause of cancer death worldwide. Carcinogen inflicted malignancies, including tobacco smoking derived lung adenocarcinoma, harbor thousands of mutations per genome. Over the last decades many new lung adenocarcinoma …
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Investigation of CD4+ T cell heterogeneity and function in a genetic mouse model of lung adenocarcinoma
… and Tregs in an inducible genetic mouse model of lung adenocarcinoma. We show that lung tumor-associated Tregs have a distinct transcriptional signature that is associated with survival in multiple cancers. Furthermore, we find that tumor-associated Treg and Tconv cells are varied and undergo …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
<p>K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that …
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Investigation of endogenous and adoptively transferred T cell function in a genetic mouse model of lung adenocarcinoma
… checkpoint blockade, including in patients with lung cancer, has clearly demonstrated that the body's immune system is capable of tumor cytotoxicity if modulated appropriately. Unfortunately, only a minority of patients with solid tumors respond to checkpoint blockade, and even fewer respond to …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… chemokines CXCL1-3 and 5-8. In non-small cell lung cancer CXCR2 has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. However, there is controversial data in the literature about CXCR2 expression in tumor cells and its role in the tumor …
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
In genetically engineered mouse models of lung adenocarcinoma (LUAD), tumors become more heterogeneous and dysregulate cell identities as they progress and evolve. In this thesis, single-cell RNA-sequencing technology was utilized to understand dynamic changes that occur during tumor evolution both …
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