Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Lung Tumor"”.
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Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
… many advances have been made in radiotherapy, tumor radioresistance and normal tissue damage continue to always be important issues for radiation oncologists. Numerous reports have also documented that radiation exposure increases the risk for malignancy and suppresses immune mechanisms. …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… field dependent targeting to the left ventral lung after thoracotomy; controls were insufflated with the NIMs in the absence of magnetic field dependent targeting. Quantification of deposition of the dye component (drug surrogate) of NIMS in left and right lung tissue showed an increase in …
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IGF1R as a pharmacological target in allergic asthma and cancer-promoting factor in the lung tumor microenvironment
… diagnósticos en etapa tardía. La progresión del tumor está influenciada por las interacciones de las células cancerosas con el microambiente tumoral (MAT). Aunque se sabe que IGF1R está involucrado en el asma y que afecta al MAT, la inhibición farmacológica de IGF1R en asma y su papel en el MAT …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… context of liver progenitor differentiation and lung tumor cell drug responses. Liver progenitor differentiation was found to be combinatorially regulated by Notch, TGFβ signaling as well as interactions with ECM proteins. The Notch ligands Jag1 and Dll1 were further found to found play distinct …
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Microfluidics for low input epigenomic analysis and application to oncology and brain neuroscience
… profile five key histone modifications in human lung tumor and normal tissue samples. Integrative analysis with gene expression data revealed extensive chromatin remodeling in lung tumor. Spatial histone modification mapping was conducted in mouse neocortex in a similar fashion. We generated an …
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Towards Intelligent Tumor Tracking and Setup Verification in Radiation Therapy For Lung Cancer
Lung cancer is the most deadly cancer in the United States. Radiation therapy uses ionizing radiation with high energy to destroy lung tumor cells by damaging their genetic material, preventing those cells from reproducing. The most challenging aspect of modern radiation therapy for lung cancer is …
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… ICB acts by reinvigorating pre-existing anti-tumor immune responses, and responders are often characterized by the presence of a T cell infiltrate in tumors. However, T cell infiltration does not always correspond to ICB efficacy. Tumor-reactive T cells can acquire persistent dysfunctional …
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Optimization under uncertainty in radiation therapy
… radiation therapy treatments of a lung tumor. We construct a robust framework that generalizes current mathematical programming formulations that account for motion. This framework gives insight into the trade-off between sparing the healthy tissues and ensuring that the tumor …
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
In genetically engineered mouse models of lung adenocarcinoma (LUAD), tumors become more heterogeneous and dysregulate cell identities as they progress and evolve. In this thesis, single-cell RNA-sequencing technology was utilized to understand dynamic changes that occur during tumor evolution both …
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Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis
Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor lesions and stages of disease progression have not been well characterized …
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Role of Phosphorylated Dicer1 In Tumor Progression
… DICER1 functions as a haploinsufficient tumor suppressor which regulates miRNAs and Epithelial-to-Mesenchymal Transition (EMT). The Arur laboratory discovered that DICER1 is phosphorylated by active ERK and that ERK-mediated phosphorylation triggers DICER1 to translocate from the …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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ANGIOTENSIN-(1-7): A NOVEL SMALL MOLECULE FOR THE TARGETED TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
… breast cancer (TNBC), an aggressive breast tumor that disproportionately affects young and minority women, is associated with a poor survival rate regardless of stage at diagnosis due to development of distant metastases. Tumors from women with TNBC lack estrogen receptors and progesterone …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… cancer risk factors such as tobacco smoking. Lung cancer is the leading cause of cancer death worldwide. Carcinogen inflicted malignancies, including tobacco smoking derived lung adenocarcinoma, harbor thousands of mutations per genome. Over the last decades many new lung adenocarcinoma …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
<p>Lung cancer remains the leading cause of cancer related deaths worldwide, reportedly contributing to 1.8 million of the 10.0 million mortalities documented in the year 2020. Although advancements have been made in therapeutics and diagnostic methods, formulation of effective treatments and …
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Improving The Accuracy of Radiation Pneumonitis Dose Response Models
<p>The prognosis for lung cancer patients remains poor. Five year survival rates have been reported to be 15%. Studies have shown that dose escalation to the tumor can lead to better local control and subsequently better overall survival. However, dose to lung tumor is limited by normal tissue …
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The effect of dietary genistein on breast cancer metastasis
… imaging (BLI) techniques to monitor the tumor progression in vivo of the two dietary groups; 2) to determine the effect of genistein on the tumor burden of the India ink-stained lungs, one of the common metastatic sites; 3) to evaluate the effect of genistein supplementation on overall …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Outcomes are poor for patients with recurrent, advanced or metastatic NSCLC. Polo-like kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in …
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