Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Lung Neoplasms"”.
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
… of imetelstat in a panel of non-small cell lung cancer (NSCLC) cell lines. Imetelstat was tested in a short-term liquid colony formation assay, a 5-day drug response assay, and long-term continuous treatment in vitro and in vivo. The panel of over 70 NSCLC cell lines used for this study …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
… metabolic heterogeneity in non-small cell lung cancer (NSCLC) and to use orthogonal high-content data sets to understand the mechanisms by which metabolic phenotypes are established in lung cancer. A major goal is to understand whether these metabolic phenotypes predict therapeutic …
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Radiographic Challenges and Considerations with Cancer Immunotherapy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Heterogeneity in Human NSCLC Tumor Glucose Metabolism: On the Origins and Role of Pyruvate Metabolism
Pages 9-96 are misnumbered as pages 10-97.
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Moving Phantom Study of Stereotactic Body Radiation Therapy for Lung Cancer
… stereotactic body radiation therapy (SBRT) lung treatment methodologies, we performed a systematic evaluation using phantoms that simulated motions from real patients (irregular motions) as well as sinusoidal motions (regular motions). The irregular patterns investigated in this study were …
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The Emergence of Diverse Drug-Resistance Mechanisms from Drug Tolerant Cancer Persister Cells
… colonies that arose from a single, EGFR-addicted lung cancer cell. We found, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies had acquired diverse resistance mechanisms, including the most commonly observed clinical resistance …
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
Lung cancer is expected to kill ~150,000 people this year, encompassing 25% of all cancer related deaths making lung cancer the leading cause of cancer-related mortality in men and women. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which …
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Regulation of Clathrin Mediated Endocytosis and Its Role in Cancer Progression
… in 29 independently isolated non-small cell lung cancer (NSCLC) cell lines to determine whether there were systematic changes in the three different endocytic pathways. However we observed significant heterogeneity. Nonetheless, using hierarchical clustering based on their combined endocytic …
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Using Multiple Screening Strategies to Biologically and Chemically Characterize Natural Products
… of ~9000 fractions to screen 26 non-small cell lung cancer cell lines for selective cytotoxic compounds. A screen of this magnitude is unprecedented in academia, therefore we developed a process to rapidly identify and characterize natural products of interest. Natural product fractions with …
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
Lung cancer accounts for more cancer-related deaths than any other cancer type among both men and women. The overall increase in radiation risk for human cancer types has been substantiated by the epidemiological data obtained from atomic bomb survivors and uranium mine workers. The lung has a …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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Targeting and Modeling Immune Resistance in Lung Cancer
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… RECEPTOR CO-ACTIVATOR 3 (SRC-3) EXPRESSION IN LUNG CANCER AND ITS ROLE IN REGULATING CANCER CELL SURVIVAL AND PROLIFERATION Steroid receptor coactivator-3 (SRC-3) is a histone acetyltransferase and nuclear hormone receptor (NHR) coactivator, located on 20q12, which is amplified in several …
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Characterization of mTOR Inhibition and Autophagy Inhibition in Non-Small Cell Lung Cancer
Lung cancer continues to be the leading cause of cancer related death in both men and women. Pre-clinical studies of targeted therapies are needed in order to improve upon the chemotherapeutics that are currently in use. The ability to identify subsets of patient tumors which will respond to a …
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Elucidation of the Mechanism of Action of a Cell Line Selective Toxin
… were selectively toxic to the same four of 12 lung cancer cell lines at low nanomolar concentrations. Sensitive cell lines expressed cytochrome P450 (CYP) 4F11, which metabolized the compounds into irreversible stearoyl CoA desaturase (SCD) inhibitors. SCD has been recognized as a promising …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… of death today in Americans. Among cancers, lung cancer is the deadliest, killing as many individuals as next 3 most lethal cancer types combined. Approximately 80% of lung cancers are a type known as non-small cell lung cancer (NSCLC), and despite numerous advances in the treatment of NSCLC, …
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Comprehensive Analysis of Lung Cancer Prognostic Factors
Lung cancer is the leading cause of death from cancer. It is remarkably heterogeneous in histopathological features and highly variable in prognosis. Analysis of prognostic factor is anticipated to guide clinicians for treatment selection, enhance patient care, and help understanding biological …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… previously unknown acquired vulnerabilities in lung cancer. Using a mini-library of 1062 lentiviral shRNAs targeting nuclear hormone receptors and their coregulators (120 genes total), we screened the lung adenocarcinoma cell line NCI-H1819 for dependency on these genes during in vitro and in …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
… selective toxicity across 100 non-small cell lung cancer (NSCLC) lines. Using photoreactive probes, we found that the QDC targets mitochondrial Complex I. We investigated the selective toxicity of Complex I inhibition across NSCLC and found that a high baseline content of aspartate formed via …
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