Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Lung Metastasis"”.
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Targeting Pd-1/Pdl-1 Signaling In The Treatment of Osteosarcoma Lung Metastasis
… (OS) manifests itself as pulmonary metastasis, which is a major cause of death in OS patients. Novel treatments like immunotherapy hold promise for the treatment of OS pulmonary metastasis. However, immunosuppressive mechanisms such as binding of immune inhibitory receptor, PD-1 with …
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Micro-CT/PET Assessment of Lung Metastasis in a Mouse Model of Osteosarcoma
… common childhood cancer. Detection of pulmonary metastasis as early as possible is vital, since the presence of and progression or regression of pulmonary metastasis critically impacts prognosis and treatment. Thus pulmonary metastatic load is a method of determining treatment response in …
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Delineating the role of prolactin-inducible protein (Pip) in breast cancer lung metastasis
… in the primary tumor in the breast, it enhanced metastasis in lungs. We hypothesized that in the lung, Pip promotes a more aggressive phenotype in the BC cells. To further address this hypothesis Pip-expressing (4T1/Pip) and control BC cells (4T1/EV) were isolated from primary tumors and …
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Combination Therapy With Aerosol Il-2 and Nk Cells For The Treatment of Osteosarcoma Lung Metastasis
<p>The survival of patients with osteosarcoma lung metastases has not improved in the last 20 years. Novel alternative therapies are needed. The purpose of this investigation was to evaluate the efficacy of combining natural killer [NK] cell therapy with aerosol interleukin-2 [IL-2] for the …
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Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
<p>Metastasis accounts for >90% of cancer-related deaths and thwarting metastasis is widely considered to be the “Holy Grail” of cancer treatment. Breast cancer is the most common cause of cancer-related death among women and is characterized by its proclivity to spread to distant secondary organs …
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Supplementation of licorice root and epimedium in a control or high fat diet and their effects on a preclinical metastatic breast cancer model
… were found to have a reduction in lung metastasis compared to control. In the high fat group, no changes in lung metastasis were found in animals supplemented with licorice root compounds compared with control. Although mild hepatocellular hypertrophy was observed in the liver of …
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
… inhibitor to inhibit tumor growth and pulmonary metastasis in animal model. The right thighs of male, 6 week old C57/BL mice were injected subcutaneous with 1 x 106 Lewis Lung Carcinoma(LLC) cells. Animals were randomized to one of six groups: no treatment(group 1), celecoxib 25mg/kg daily per …
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Adhesion-GPCRs in cancer progression and metastasis
… possible roles in breast cancer progression and metastasis. Based on these analyses and cross-referencing with the published gene expression data on human breast cancer cell lines and patient samples, I chose two candidate genes, CELSR2 and GPR126, for more detailed investigation. To elucidate …
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Effect of Entinostat On Nk Cell-Mediated Cytotoxicity Against Os Cells and Os Lung Metastsis
… on the efficacy of NK cell therapy for OS lung metastasis. The Lung is the most common site of OS metastatic spread in OS and pulmonary metastasis is the main cause of mortality. We have previously demonstrated that NK cell therapy has minimal efficacy against OS metastasis. We wished to …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… models of 3-methylcholanthrene (MCA)-induced lung metastasis, colon cancer-derived liver metastasis and diethylnitrosamine (DEN)-induced hepatocellular carcinoma. The number and dimension of liver and lung metastasis and the liver disease severity were significantly reduced in …
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4D Ex Vivo Crispr/Cas9 Whole-Genome Screen to Identify Genes Regulating Lung Cancer Metastasis
<p>Metastatic lung cancer has a 5-year survival rate of 5%. Lung cancers tend to be asymptomatic until late stages, and almost 90% are not diagnosed until they are advanced. Metastases are very rare events, often initiated by a single cell from a primary tumor into a new niche at a distant …
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… 3 agonists to reduce osteosarcoma metastatic lung tumor burden in a clinically-relevant murine model of osteosarcoma, utilizing the highly aggressive K7M2 osteosarcoma cell line. This model employs tail-vein injection of the neoplastic K7M2 cells, which subsequently shower the lungs and …
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Therapeutic and chemopreventive potential of luteolin against growth and metastasis of breast cancer
… of breast cancer, and inhibit its growth and metastasis. LU effectively blocked progestin (P)-induced intratumoral vascularization in our animal models when given preventatively or therapeutically. LU blocked P-stimulated effects in cultured human breast cancer cells, including inhibiting the …
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Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
… To study the role(s) of HLGAGs in cancer growth, metastasis and angiogenesis, tumor systems were studied using heparinases I and III which have distinct substrate specificities. Studies, focusing on the biochemistry of the heparinase active site, elucidated key interactions important for enzymatic …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… ameliorated splenomegaly, but not affected the lung metastasis. Moreover, the therapeutic effect of Akt inhibition was potentiated in combination with carfilzomib. In conclusion, targeting Akt signaling may represent an attractive potential therapeutic target for the HS. Future studies are …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
The leading cause of cancer deaths is tumour metastasis. The formation of metastases is a complex multistep process, involving invasion of the basal membranes and connective tissue, penetration of the blood vessel walls, invasion of the host tissue, and initiation of growth at the new location. The …
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Targeting Calpain-1 and Calpain-2 for Prevention of Breast Cancer Metastasis: In Vivo Insights and Drug Discovery Approaches
… which could perhaps ameliorate the metastasis-linked decline in breast cancer patients’ survival. Calpain-1 and -2, ubiquitous calcium-dependent cysteine proteases, are a potential novel therapeutic target in cancer as they are upregulated in multiple cancer subtypes, including …
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Investigating The Effects of Silencing Epha2 In Metastatic Breast Cancer Cells
… in cancers such as those of the prostate, colon, lung, and breast. For breast cancers, EphA2 overexpression is most prominent in the ER-negative subtype, and is associated with a higher rate of lung metastasis. Studies conducted to demonstrate the role of EphA2 in a non-cancerous environment have …
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Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin
… potent inducer of tumor growth and experimental lung metastasis. Our data elucidate a previously unidentified mechanism by which galectin-3 regulates autotaxin and assign a novel role for NFAT1 during melanoma progression.</p>
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The Role Of Pkc Epsilon In Breast Cancer Cell Surface Polyfibronectin Assembly And Pulmonary Metastasis
… of breast cancer cells has been shown to mediate metastasis to the lungs. Disruption of the binding between these tumor-cell surface-associated fibronectin, or polymeric fibronectin (polyFn), and dipeptidyl peptidase (DPPIV) negatively impacts breast cancer lung colonization. This dissertation was …
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