Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Lung Carcinogenesis"”.
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Effects of Radiation Exposure on Lung Carcinogenesis
Lung cancer is one of the most prevalent forms of cancer in both men and women with over 1.3 million annual related deaths worldwide. Analysis of several human populations exposed to radiation reveals that the lung is remarkably susceptible to the carcinogenic effects of radiation exposure. The …
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
Lung cancer accounts for more cancer-related deaths than any other cancer type among both men and women. The overall increase in radiation risk for human cancer types has been substantiated by the epidemiological data obtained from atomic bomb survivors and uranium mine workers. The lung has a …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
… progression of early lesions. Chemoprevention of lung cancer aims to decrease lung cancer morbidity and mortality, especially for former smokers. Many synthetic and natural compounds have been investigated for their potential chemopreventive efficacy. Conventional administration of these …
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Lung carcinogenesis modeling: Resampling and simulation approach to model fitting, validation, and prediction
Because of serious health implications, lung cancer is the leading cancer killer for both men and women. It is well known that smoking is the major risk factor for lung cancer. I propose to use a two-stage clonal expansion (TSCE) model to evaluate the effects of smoking on initiation and promotion …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… cancer risk factors such as tobacco smoking. Lung cancer is the leading cause of cancer death worldwide. Carcinogen inflicted malignancies, including tobacco smoking derived lung adenocarcinoma, harbor thousands of mutations per genome. Over the last decades many new lung adenocarcinoma …
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Induction of Synthetic Lethality In Mutant Kras Cells For Non-Small Cell Lung Cancers Chemoprevention and Therapy
<p>Lung cancer is the leading cause of cancer death in both men and women in the United States and worldwide. Despite improvement in treatment strategies, the 5-year survival rate of lung cancer patients remains low. Thus, effective chemoprevention and treatment approaches are sorely needed. …
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Biology of the envelope glycoproteins of sheep betaretroviruses
… adenocarcinoma (OPA), a naturally occurring lung cancer of sheep. The JSRV Env glycoprotein is a dominant oncoprotein and its expression is sufficient to induce cell transformation in vitro and in vivo. Thus, OPA is a unique large animal model for the study of lung carcinogenesis. The sheep …
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Spray Techniques And Lung Cancer Chemoprevention
… promising approach to decrease the incidence of lung cancer in current and former smokers. Directly delivering drugs to the lung could lead to a high concentration in the target organ with a lower dose compared to other means of administration. The primary advantages of aerosol delivery in …
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A study of gene expression in human normal and carcinogenic cell lines using qRT-PCR
The susceptibility of human lungs to carcinogens depends on the metabolic balance between activation and detoxification pathways, though for the tumour to develop depcnds on activation of cell immortalisation pathway. The correlation of these pathways has not been reported. The present study …
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Identifying mutational landscape and inflammatory pathways associated with lung squamous premalignant lesion progression
Lung cancer is the leading cause of death among all cancer types, and a subtype of lung cancer known as lung squamous cell carcinoma (LUSC) is the second most predominant subtype accounting for ~30% of all lung cancer cases. Lung cancer is typically diagnosed at advanced stages, resulting in poor …