Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 642 for “"Lung Cancer"”.
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Nuclear Receptors in Lung Cancer
Lung Cancer is a fatal disease with new diagnoses of more than 150,000 Americans every year. Although it has a relatively well-known etiology (e.g. smoking) and has been widely researched, clinical tools and markers for early diagnosis, prognostic prediction, and therapeutic interventions remain …
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Spray Techniques And Lung Cancer Chemoprevention
… promising approach to decrease the incidence of lung cancer in current and former smokers. Directly delivering drugs to the lung could lead to a high concentration in the target organ with a lower dose compared to other means of administration. The primary advantages of aerosol delivery in …
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Symptom Clusters in Lung Cancer Patients
SYMPTOM CLUSTERS IN LUNG CANCER PATIENTS By Debra Rattican, PhD, RN A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Debra E. Lyon, PhD. Professor …
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Dissecting Tumor Heterogeneity In Lung Cancer
<p>Lung cancer is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells as well as a heterogeneous microenvironment consisting of non-cancer cells and extracellular matrix. Constant interactions among these components ultimately leads to a complex tumor tissue that …
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Targeted magnetic hyperthermia for lung cancer
Lung cancer (specifically, non-small cell lung cancer; NSCLC) is the leading cause of cancer-related deaths in the United States. Poor response rates and survival with current treatments clearly indicate the urgent need to develop an effective means to treat NSCLC. Magnetic hyperthermia is a novel …
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Survival analysis for lung cancer patients
Cancer is one of the leading causes of death. Lung cancer, in particular, is the leading cause of cancer death in both men and women, accounting for 23% of all cancer deaths in 2019 according to the Centers for Disease Control and Prevention. One particular problem with lung cancer is that it …
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Canine scent detection: Lung cancer target acquisition
… were trained to detect the presence of lung cancer in human breath and saliva samples. Operant conditioning processes and an automated apparatus were used to train and test the dogs. Data for all three experiments were collected concurrently. The experiments involved: designing a process …
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
A rising trend in lung cancer chemotherapy involves the development of agents that exploit molecular targets overexpressed in tumors, with hopes of increasing specificity, and in turn, efficacy. β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by …
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Comprehensive Analysis of Lung Cancer Prognostic Factors
Lung cancer is the leading cause of death from cancer. It is remarkably heterogeneous in histopathological features and highly variable in prognosis. Analysis of prognostic factor is anticipated to guide clinicians for treatment selection, enhance patient care, and help understanding biological …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
Lung cancer causes the maximum number of cancer related deaths worldwide. In recent years, the cancer genome atlas (TCGA) initiative has identified 138 frequently occurring driver oncogenes and tumor suppressor genes in lung cancer. Currently, only 15 of these genes can be targeted therapeutically. …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
Small cell lung cancer (SCLC) is an understudied tumor subset with aggressive neuroendocrine carcinoma features. Previous studies have determined that the basic helix-loop-helix (bHLH) transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many …
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Precision Medicine in Immunotherapy and Lung Cancer
… chemotherapy or immunotherapy for non-small cell lung cancer, and combines potential biomarkers from simple immunohistochemistry to advanced single-cell RNA sequencing data to predict immunotherapy toxicity. Outline The first chapter of this thesis explores the role of immunohistochemistry markers …
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Radiotherapy in Non-Small-Cell Lung Cancer
Contains fulltext : 30924_radiinnol.pdf (Publisher’s version ) (Open Access)
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Radiotherapy induced toxicity in lung cancer patients
Contains fulltext : 194287.pdf (Publisher’s version ) (Open Access)
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Role of RNA methyltransferases in lung cancer
… because their activities are relevant to cancer biology, and they are therefore potential targets for novel therapeutic intervention. Here, I target validated two RNA methyltransferases. I performed a late-stage study of METTL3, and I initiated and developed an early-stage analysis of …
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Oncogene-driven post-transcriptional regulation in lung cancer
Lung cancer is often caused by genetic mutations which alter the activity of proteins in the RAS family, with somatic mutation of the KRAS gene occurring in ~30% of lung adenocarcinoma tumors. A gene of the same family, RIT1, is mutated or amplified in 10-15% of lung adenocarcinomas. Although …
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Targeting and Modeling Immune Resistance in Lung Cancer
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Glucocorticoid resistance in COPD patients and lung cancer
… and the surrounding microenvironment in the lung tissue. Glucocorticoids are the main treatment for many inflammatory diseases, however, the majority of COPD patients are resistant to glucocorticoids, so a better understanding of the exact mechanism of glucocorticoid resistance in COPD …
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Development of an inhalable nanomedicine for lung cancer
Lung cancer affects over 2 million people worldwide and became the major cause of death in cancer patients (18.4%) in 2018. The treatment of non-small cell lung cancer (NSCLC), accounting for 85% of total lung cancer, involves chemotherapy, radiotherapy, and surgery. However, such a therapeutic …
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