Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2387 for “"Lung"”.
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REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS
… characterized by the replacement of functional lung parenchyma with fibrotic tissue. PF develops due to chronic injury to the lungs, and leads to decreased lung compliance, function and a significant reduction in the quality of life for the patient. Currently, there are no treatments available …
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Lung mechanics in the aging lung and in acute lung injury. Studies based on sinusoidal flow modulation.
Knowledge about lung mechanics is of interest in intensive care to adjust mechanical ventilation and in the lung laboratory for diagnostics and evaluation of patients with various kinds of respiratory diseases. In mechanical ventilation a single inspiratory elastic pressure-volume (Pel/V) curve is …
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Lung Perfusion CT: Differentiation between Lung Cancer and Progressive Massive Fibrosis
… between progressive massive fibrosis and lung cancer. MATERIALS AND METHODS: We retrospectively analyzed the perfusion CT image of 20 lesions in 13 patients with progressive massive fibrosis. Using 16 channel multi-detector CT, a dynamic study was performed by a multiple spiral acquisition …
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Chemoprevention of Lung Carcinogenesis: Aerosol Administration and Deposition in the Mouse Lung
… progression of early lesions. Chemoprevention of lung cancer aims to decrease lung cancer morbidity and mortality, especially for former smokers. Many synthetic and natural compounds have been investigated for their potential chemopreventive efficacy. Conventional administration of these …
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Vitamin D status and longitudinal lung function decline in the Lung Health Study
… are postulated to be a risk factor for worse lung function, largely based on cross-sectional data. We sought to use longitudinal data to test the hypothesis that baseline plasma 25-hydroxyvitamin D [25(OH)D] is lower in subjects with more rapid lung function decline, compared to those with …
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Lung tissue engineering : in vitro synthesis of lung tissue from neonatal and fetal rat lung cells cultured in a three-dimensional collagen matrix
… days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures …
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Selection Bias In Lung Allocation: Influence On Lung Allocation Score And Physician Decision-Making
In the U.S., donor lungs are allocated to recipients based on a lung allocation score (LAS). While the statistical models used to construct the LAS control for patients’ demographic and clinical values, they do not account for selection bias, which arises because: (1) individuals are removed from …
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The Role of Bone Morphogenetic Protein (BMP) Signalling in Lung Cancer and Lung Regeneration
… is known regarding the role of BMPs in adult lungs during health and disease. In the present study, the role of BMP signalling in lung cancer and lung regeneration processes was examined. Early lung cancer tumours were isolated by laser capture microdissection from Kras G12D mouse lungs and …
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Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis
Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor lesions and stages of disease progression have not been well characterized …
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Nuclear Receptors in Lung Cancer
Lung Cancer is a fatal disease with new diagnoses of more than 150,000 Americans every year. Although it has a relatively well-known etiology (e.g. smoking) and has been widely researched, clinical tools and markers for early diagnosis, prognostic prediction, and therapeutic interventions remain …
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Tissue repair in lung disorders
The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main …
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LUNG PATTERN CLASSIFICATION VIA DCNN
<p>Interstitial lung disease (ILD) causes pulmonary fibrosis. The correct classification of ILD plays a crucial role in the diagnosis and treatment process. In this research work, we disclose a lung nodules recognition method based on a deep convolutional neural network (DCNN) and global features, …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… accurately. Here, we bioengineered a human lung tissue model that represents small airway structures with tissue-resident and circulatory immune cells. The immune-competent lung tissue model comprises of a 3D, perfusable microvascular network underneath a mature, differentiated epithelium at …
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Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer
Lung cancer is the leading cause of cancer-related death worldwide. Among lung carcinomas, the outcome of small cell lung carcinoma (SCLC) patients is the poorest of any histological subtype with five-year survival rate of less than 20 and 5 % for limited and extensive stage respectively. Based on …
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Prediction of post-tuberculosis lung damage using CT lung imaging measures among adults in Malawi
… TB treatment can mark the beginning of chronic lung damage and other sequelae. There is a need for early identification of individuals at risk of post-tuberculosis lung damage (PTLD) to necessitate its appropriate management. This study evaluated the significance of radiological features from …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… cancer risk factors such as tobacco smoking. Lung cancer is the leading cause of cancer death worldwide. Carcinogen inflicted malignancies, including tobacco smoking derived lung adenocarcinoma, harbor thousands of mutations per genome. Over the last decades many new lung adenocarcinoma …
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Quantitative Assessment of Lung Microstructure in Healthy Mice Using an MR-based 3He Lung Morphometry Technique
… in our laboratory the MRI-based technique - 3He Lung Morphometry - is a unique tool allowing in vivo measurements of lung microstructural parameters such as alveolar volume, surface-to-volume ratio and alveolar density. These parameters are commonly used by lung physiologists and pathologists but …
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Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
… great need for research models that mimic human lung physiology and lung pathologies such as chronic lung diseases and respiratory infections. The morbidity and mortality associated with lung disease and respiratory infections represent a global burden. Pathogenesis of these diseases and …
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Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
… studies have determined separate populations of lung progenitor cells that give rise to lung adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional knockout mouse …
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