Global ETD Search
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Showing 1 to 4 of 4 for “"Lubricin"”.
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Regulation of lubricin gene expression and synthesis in cartilage by mechanical injury
… load distribution and frictionless motion. Lubricin, a glycoprotein which concentrates at the superficial layer of the cartilage, contributes to the low friction coefficient. Mechanical injury to cartilage increases the risk of osteoarthritis (OA), characterized by degradation of articular …
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Therapeutic Potential of TRP Channels in the Targeting of Rheumatoid Arthritis Synovial Fibroblasts
… of lubricating components hyaluronic acid and lubricin that allow for ease of movement. Together with macrophages, they make up the synovial lining and sub-lining in roughly equal proportion. Proinflammatory cytokine production in the inflamed joint leads to synovial fibroblast proliferation …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… Synoviocytes produce proteoglycan-4 (PRG4; lubricin), a heavily glycosylated mucinous glycoprotein, and hyaluronic acid (HA). Both PRG4 and HA compete for binding to the CD44 receptor. Furthermore, rhPRG4 binds to TLR2 and TLR4 and acts as an antagonist to prevent TLR2 and TLR4 activation by …
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Proteoglycan-4 in Equine Joint Disease, Exercise, and in vitro Cartilage Repair
Proteoglycan-4 (PRG4) and hyaluronan (HA) are biological macromolecules with varied and diverse functions distributed throughout the body. In synovial fluid (SF), PRG4 and HA provide independent and synergistic contributions to tissue health and cartilage boundary lubrication. The biological …