Global ETD Search
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Showing 1 to 5 of 5 for “"Lsr2"”.
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The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis
Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide range of genes involved in cell wall synthesis …
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Prevalence of the gene lsr2 among the genus Mycobacterium and an investigation into changes in biofilm formation when inactivating lsr2 regulated genes in Mycobacterium smegmatis
… however, when the DNA-regulating protein Lsr2 is inactivated the bacteria forms a smooth colony and loses biofilm formation. This study investigates the phenotypic effect on colony morphology and biofilm formation when Lsr2-regulated genes are inactivated. A mutant strain of M. smegmatis …
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Targeting Lsr2/DNA Complexation for Dysregulation of Gene Expression in <i>Mycobacterium tuberculosis</i>
… strains has made many treatments ineffective. Lsr2 is a protein encoded by the <i>Mycobacterium tuberculosis</i> genome that acts as a global repressor of transcription by binding AT-rich promoter regions of the mycobacterial DNA. Inhibiting this function could potentially dysregulate a wide …
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Investigations into the Phage-Host Dynamics of Streptomyces
… metabolism. One gene of particular interest is Lsr2, a bacterial gene that is present in 11 of our sequenced phages. Lsr2 is a xenogeneic silencing protein that silences foreign DNA in bacteria. Xenogeneic silencers have been shown to bind to and silence prophage genes genomes and many phages …
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Nucleoid-Associated Proteins of Streptomyces coelicolor: Discovery and Functions
… list included known NAPs such as HupA, HupS, Lsr2 and sIHF and the known global regulators CRP and BldD, as well as a number of interesting novel NAP candidates from a variety of protein classes suitable for further investigation. One of these proteins, SCO5592, was investigated as a candidate …