Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Loxl2"”.
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Examining The Role Of Lysyl Oxidase Enzymes In Atrial Fibrillation Induced By Volume Overload
… infiltration 2-fold compared to sham mice. LOXL2 inhibitor PXS-5382 reduced AF inducibility, shortened AF duration and attenuated fibrosis without affecting AERP. In contrast, the broader LOX inhibitor PXS-5505 prevented fibrosis without reducing AF inducibility in AR mice but exacerbated AF …
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New Designs of Electrochemical H2O2 Based Biosensors For Advanced Medical Diagnosis
… by a potential biomarker, lysyl oxidase like 2 (LOXL2), on the developed electrochemical biosensor. The aberrant LOXL2 expression can be observed in poorly differentiated, high-grade tumors, and, predicted for the acquisition of chemo-resistance, recurrent phenotypes, and overall patient survival …
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The Association of demographic and physiological variables and risk of subsequent disease progression in idiopathic pulmonary fibrosis
… 2 baseline exploratory endpoints (serum LOXL2 and fibrosis score from quantitative high-resolution computed tomography and the change in forced vital capacity (L) over 14 weeks (prodromal ΔFVC) from placebo-treated patients, were used to generate predictive models for weeks 14–66 for …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… of the collagen crosslinking enzyme LOXL2. Coordinated expression of LOXL2 with collagen increases insoluble collagen crosslinking and deposition in the tumor microenvironment, resulting in activated Fak/Src signaling to promote metastasis. Using functional <em>in vivo</em> shRNA …
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Pericyte deficiencies in a foxf2 loss of function mutant
… effects. A downstream target of foxf2a, loxl2b, is downregulated in foxf2 mutants. While loxl2b mRNA is sufficient to boost brain pericyte numbers, mutants for this gene do not show an obvious phenotype, suggesting a more complicated role. This thesis sheds light on novel lifespan defects …