Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Low-density lipoprotein receptor"”.
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Post-translational processing of the low density lipoprotein receptor
The low density lipoprotein (LDL) receptor is a transmembrane glycoprotein that mediates the uptake of plasma LDL and thereby provides cholesterol to cells. During its synthesis in the endoplasmic reticulum, the LDL receptor folds and forms disulfide bonds in multiple cysteine-rich repeats. N- and …
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… I identified this locus as a member of the low-density lipoprotein receptor-related protein (LRP) family, and designated it lrp13b. I have found that ethanol teratogenesis in lrp13b mutants is made more severe by increased developmental temperature. Mutants in lrp13b experienced increased …
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The cellular degradation of the low density lipoprotein receptor and its ligand
The cellular degradation of the low density lipoprotein (LDL) receptor, and its ligand, LDL, were investigated in order to clarify certain mechanistic aspects of these important processes. Long-term lymphoblastoid cell lines and cultured human skin fibroblasts were used to examine the fate of …
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The characterisation of the ectodomain shedding of the low density lipoprotein receptor
Includes abstract. Includes bibliographical references (leaves 142-155).
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… biosynthetic pathway. Megalin, a member of the low density lipoprotein family of receptors, is sorted apically in polarized epithelial cells via a sorting signal present in its cytosolic domain. I show that the cytosolic domain of megalin associates with sorting nexin 17, a protein that …
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
… has emerged as a central regulator of plasma low-density lipoprotein cholesterol levels. Here, it is demonstrated that PCSK9 is secreted into the blood and that the secreted PCSK9 binds and degrades LDLRs in liver. To determine if PCSK9 catalytic activity was involved in the degradation of the …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… in the cortical plate. Reelin binds to apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) that are members of lipoprotein receptor family, and induces the tyrosine phosphorylation of disabled1 (Dab1), an adaptor protein binding to cytoplasmic domain of …
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Die Körnerzellposition beeinflusst die Faserschichtung der Fascia dentata der Maus : eine Studie an Reeler, Apolipoprotein E Receptor 2 defizienten und Very Low Density Lipoprotein Receptor defizienten Mäusen
… von drei verschieden Mausmutanten (very-low-density Lipoproteinrezeptor defizienten, Apolipoprotein E Rezeptor 2 defizienten und reeler Mäusen) mit unterschiedlich stark ausgeprägten Körnerzellverteilungsstörungen untersucht. Die afferenten Fasersysteme wurden mit dem anterograden Tracer …
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
… across the plasma membrane to combine with apolipoproteins, forming nascent high density lipoproteins (HDL), the precursor of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, characterized by extremely low plasma HDL cholesterol (HDL-C) levels and widespread storage of cholesterol …
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Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer
… expression of the estrogen and progesterone receptors, and normal expression of the human epidermal growth factor receptor 2. The lack of a well-characterized target for treatment leaves only systemic chemotherapy as the mainstay of treatment. Approximately 60-70% of patients are …
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Techniques for identifying long-range residue correlations in the fifth binding module of LDLR
… was the fifth binding module (LR5) of the low-density lipoprotein receptor (LDLR) which regulates the cholesterol level in the bloodstream.
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Regulation of Myeloid Leukemia Cells by Platelet Factor 4
… found that PF4 preferentially acts on LSCs via low-density lipoprotein receptor (LDLR) to inhibit their proliferation and deregulate lipid metabolism. When given in combination with chemotherapy, PF4 prolongs the overall survival of leukemic mice. Collectively, our results indicate that PF4 …
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Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
… is primarily dependent on endocytosis via the low-density lipoprotein receptor. The nanoparticles are rapidly turned over and display minimal toxicity to cultured neurons. Delivery of three different functional cargo proteins is demonstrated. When primary neuronal cultures are treated with …
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Novel gene delivery systems for brain targeting
… genes in global areas of the CNS. Various receptors such as transferrin receptors, lactoferrin receptors and low-density lipoprotein receptor-related proteins 1 & 2 are widely expressed on the blood-brain barrier for the transport of endogenous molecules. These endogenous transport systems …
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Role of Reelin-Dab1 Signaling in the Neuritogenesis
… in the Cajal-Retzius cell that binds to the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), inducing tyrosine phosphorylation of Dab1, a cytoplasmic adaptor protein of receptors. The Reelin-Dab1 signaling is regulatory key to migration and positioning of …
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The Role of Wnt Signaling in Bone Mechanotransduction
… characterized by increased fracture risk and low bone mass. In skeletal tissue, canonical Wnt signaling is a critical regulator of bone mass, and dysregulation of the Wnt pathway has been implicated in numerous skeletal displasias. Some components of the Wnt signaling pathway have a clear role …
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The Development of a Drug Delivery System Using Brain Endothelial Non-Antibody Binding Domains as Transport Carriers
… system (CNS) a challenging feat. Endogenous BCEC receptors such as transferrin receptor (TfR) have been proposed as exploitable targets for therapeutic payload transport into the CNS, and have been successfully targeted using monoclonal antibodies to deliver therapeutic molecules into the brains …
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