Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Low-coherence interferometry"”.
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Optical characterization of human tissues using low coherence interferometry
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
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Quantifying tympanic membrane dynamics in otitis media using low coherence interferometry
… analysis of the TM dynamics, a pneumatic low-coherence interferometry (LCI) otoscope was developed with automated pressure generation. The pneumatic LCI system developed during this research measures the TM displacement with an axial resolution of around 6.5 μm, and provides simultaneous …
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Development of a Fourier Domain Low Coherence Interferometry Optical System for Applications in Early Cancer Detection
… of one such technique called Fourier domain low coherence interferometry (fLCI). </p><p>The presented work first describes a detailed analysis of temporal and spatial coherence. The study shows that temporal coherence information in time frequency distributions contains valuable structural …
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Harmonic phase based low coherence interferometry : a method for studying the dynamics and structures of cells
… The unprecedented accuracy can potentially allow us to track subtle chemical changes in biological targets. Finally, we present the theoretical considerations of a method for suppressing turbidity in a scattering medium through the simultaneous use of phase conjugation and plane reflection. We …
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Non-invasive assessment of biofilm growth in the middle ear using a portable low-coherence interferometry system
… be recognized using a regular otoscope. However, lowcoherence interferometry (LCI) is capable of detecting and quantifying this microstructure. The goal of this research was to design a portable system integrating LCI with a standard video otoscope to detect the presence of biofilms and provide …
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Non-invasive assessment of bacterial biofilm in the middle ear using low-coherence interferometry/optical coherence tomography and acoustic measurements
… biofilm in the middle ear using two methods, low coherence interferometry (LCI)/optical coherent tomography (OCT) and acoustic measurements. Portable systems were constructed by integrating LCI/OCT techniques with a standard video otoscope to provide depth-resolved optical scattering …
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Novel Low Coherence Interferometric Tools for Early Detection of Cancer
… cervical and colorectal cancer, exhibit very slow growth and histological evidence on or close to the tissue surface of precancerous development. With appropriate methods, the cancer can be detected before it has the chance to actually become malignant, and safely removed, preventing additional …
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Novel Biophotonic Imaging Techniques for Assessing Women's Reproductive Health
… imaging of fluorimetry and multiplexed low coherence interferometry (mLCI) to measure in vivo microbicide gel thickness distributions. The study explores the optical performance of the device and provides proof of concept measurements on a calibration socket, tissue phantom, and in vivo …
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Low coherence speckle interferometry (LCSI) for the characterisation of adhesive bonded joints
Low Coherence Speckle Interferometry (LCSI) combines depth-resolved measurements of Low Coherence Interferometry and high-accuracy deformation measurements of Electronic Speckle Pattern Interferometry. Depth-resolved deformation measurements enable e.g. the characterisation of the behaviour of …
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High speed handheld instrument for ophthalmic optical coherence tomography
Optical coherence tomography (OCT) is a non-contact, high resolution biomedical imaging technique that uses low coherence interferometry to generate cross-sectional images of tissue. OCT has become a standard tool in ophthalmology for imaging the retina to detect or monitor pathologies. Recent …
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Applications of Fourier Domain Mode Locked lasers for optical coherence tomography imaging
Optical coherence tomography (OCT) is a micrometer-resolution imaging technique that produces cross-sectional images of sample microstructure by measuring the amplitude and echo time delay of backscattered light. OCT imaging is performed using low-coherence interferometry, typically with a fiber …
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Development and translation of label-free functional microscopy based on optical coherence tomography
Optical coherence tomography (OCT), an imaging modality based on low coherence interferometry, can be extended to obtain various endogenous functional contrasts. This thesis focuses on the development and translation of angiographic and polarization sensitive (PS) OCT techniques for clinical and …
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Minimally invasive diagnostic imaging using high resolution Optical Coherence Tomography
… and understand biological systems. Optical Coherence Tomography (OCT) is a high speed, high resolution imaging technique that utilizes low coherence interferometry to perform cross-sectional tomographic imaging of tissue in real time and in vivo. The design, development, and implementation …
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Interrogation of fibre optic sensors
… grating, an acousto-optic tuneable filter and low-coherence interferometry to measure dynamic strain and displacement using fibre Bragg grating and interferometric sensors. Based on the intrinsic properties of arrayed waveguide gratings and acousto-optic tuneable filters used in conjunction …
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High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging
Optical coherence tomography (OCT) is a novel biomedical imaging technique that functions as a type of "optical biopsy" by using low coherence interferometry to non-invasively generate high resolution cross-sectional images of tissue in real time. OCT has become a standard diagnostic tool in …
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Spectral/ Fourier domain Doppler Optical Coherence Tomography in the rodent retina
Optical Coherence Tomography (OCT) is an emerging imaging technique based on low-coherence interferometry for noninvasive, high- resolution, cross-sectional imaging in a variety of biomedical fields. In ophthalmology, OCT has rapidly become a standard clinical diagnostic tool for retinal diseases, …
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Optical measurement of neural action potentials using low coherence heterodyne interferometry
… for detection of neural action potentials using low coherence interferometry. The dual beam heterodyne interferometer (DBHI) is a modified Michelson with a low coherence source and an optical referencing method capable of detecting sub-nanometer optical path changes. In this interferometer, …
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Quantitative phase microscopy for the study of electromotility in living cells
… improved quantitative phase microscope based on low-coherence interferometry with enhanced sensitivity and lower noise. We successfully acquired images of the intrinsic optical signal from electrically stimulated single HEK293 cells. In Chapter 4, we characterized the electrochemical properties …
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Endoscopic optical coherence tomography for clinical studies in the gastrointestinal tract
Optical coherence tomography (OCT) performs micrometer-scale, cross-sectional and three dimensional imaging by measuring the echo time delay of backscattered light. OCT imaging is performed using low-coherence interferometry. With the development of Fourier domain detection techniques and …
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Enhanced Vasculature Imaging of the Retina Using Optical Coherence Tomography
<p>Optical coherence tomography (OCT) is a non-invasive imaging modality that uses low coherence interferometry to generate three-dimensional datasets of a sample's structure. OCT has found tremendous clinical applications in imaging the retina and has demonstrated great utility in the diagnosis of …
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