Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Low toxicity"”.
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The effects of PVP(FE(III)) catalyst and polymer molecular weight on gene delivery via biodegradable crosslinked polyethylenimine
… due to their availability, simple chemistry, and low toxicity and immunogenicity. Our group has previously reported biodegradable polyethylenimines (PEI) that show high transfection efficiency and low toxicity by cross-linking 800 Da PEI with diacrylate cross-linkers using Michael addition. …
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Elucidation of Design Criteria for siRNA Delivery in Mammalian Cells Using Polyethylenimine
… PEI to deliver siRNA. Acetylated PEI have lower buffering capacity, better dissociation, and less toxicity than unmodified 25-kDa PEI. The results indicate that acetylated PEI are less efficient than unmodified PEI. It seems as though buffering capacity significantly affects endosomal …
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Development and characterization of novel toxoplasma gondii inhibitors
… Treatments currently available are limited by toxicity and teratogenicity. This necessitates the development of novel drug compounds. Tryptanthrin and its analogue, 8-bromotryptanthrin, have shown promise in the treatment of <italic>Toxoplasma gondii in vitro</italic>. New tryptanthrin …
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Experimental characterization and computational modeling of N-doped Carbon Dots for future optoelectronic applications
… materials. A promising green and low-cost alternative is currently represented by carbon-based nanoparticles known as Carbon Dots that generally display low toxicity and excellent biocompatibility. Their most important feature is their efficient fluorescence in the visible region …
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RECYCLING OF WASTE BLOOD INTO FUNCTIONAL CARBON NANOPARTICLES
… with minimal impact on blood viscosity and low toxicity, indicating high biocompatibility. This work highlights the feasibility of transforming blood waste into valuable nanomaterials, proposing a sustainable solution for waste management and contributing to advanced anticoagulant …
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
… for 72 hours. Both DHA and 5-Fluorouracil slowed growth significantly (p < 0.05). In contrast, vitamin D did not inhibit cell growth at 1 μM. The combination of vitamin D and DHA inhibited cell growth slightly more than DHA alone. Interestingly, DHA was just as effective as 5-Fluorouracil at …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… (PNP), named CAR-APP-F4/80, with small size, low toxicity and strong targeting for efficient CAR-mRNA delivery to TAMs. Its excellent mRNA encapsulation efficiency and successful cell uptake and endosome escape in RAW264.7 were proved. CAR-APP-F4/80 showed strong transfection ability and high …
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The Discovery and Chemical Synthesis of Peptides and Proteins that Cross Biological Barriers
… to the cytosol with high peptide stability and low toxicity. In-cell PS-MS introduces a method to discover unnatural synthetic peptides to delivery therapeutically relevant cargo into subcellular compartments. The chromatographic enrichment of a peptide library through cation-exchange …
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QUB-2454: a bioactive peptide from the frog skin secretion of Phyllomedusa palliate
… potent antimicrobial activity but exhibit low toxicity against eukaryotic cells. In a recent study, potent antimicrobial activity was correlated with the conserved structures and cationic amphiphilic characteristics of members of this peptide family. A dermaseptin peptide precursor was …
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Management strategy of landfill leachate and landfill gas condensate
… absorbance (SUVA254) of the three fractions follows: HA > FA > Hpi. However, the overall UV254 absorbance of the Hpi fraction was important because there was more hydrophilic organic matter than humic or fulvic acids. It was found that the size distribution of the three fractions follows: HA > …
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QUB-1951: a bioactive peptide from the skin secretion of the Chinese piebald Odorous frog, Odorrana schmackeri
… potential combining high efficacy with low toxicity. <br/><br/>In this research, a bioactive peptide was obtained from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri). The precursor encoded cDNA was identified by using “shotgun” cloning, with the amino acid …
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Specificity of Interaction of Antimicrobial Peptide with Cell Membrane
… antibiotics with novel mechanisms of action and low toxicity to combat this issue. Antimicrobial peptides (AMPs) represent a promising solution. These peptides exhibit broad-spectrum antimicrobial activity and rapid killing kinetics, reducing the likelihood of resistance development. AMPs …
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Thermodynamical, structural, and dynamical characterization of solvent mixtures of technological interest: experimental and computational studies
… solvents with “green” characteristics, such as low volatility and low toxicity. They can be used as a valid alternative to the common organic solvents with a high environmental, health and safety impact. The aim of my research was to investigate their thermodynamical, structural, and dynamical …
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Evaluation of TiO2 as a Pt-Catalyst Support in a Direct Ethanol Fuel Cell
… density, ease of distribution and handling, and low toxicity of ethanol. Difficulties lie in finding a catalyst that can completely oxidize ethanol and resist poisoning by intermediate reaction species. Degradation of the catalyst layer over time is also an issue that needs to be addressed. In …
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Reversibly neutralized perfringolysin O for intracellular delivery of macromolecules/
… whose pores, reaching up to 30nm in diameter, allow the passage of large molecules without a specialized transport mechanism. However, the creation of such pores on the cell membrane is accompanied by cytotoxicity, which limits the practical use of these proteins as a delivery tool. Thus, we …
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Two-Dimensional Titanium Carbide MXene for Lithium-ion Conductive Solid-state Electrolytes
… using a mild etching approach involving low-toxicity acids, enabling a safer and more environmentally friendly alternative to traditional synthesis methods. The resulting MXene was characterized using X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive …
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Avaliação da estabilidade física de emulsões contendo limoneno
… many advantages for therapeutic use , such as low toxicity , biodegradability , and are renewable for availability in relation to petroleum that are finite , among these oils have limonene which features various activ ities among them gastroprotective function front of gastric ulcers induced by …
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Phase behavior and phase transformation kinetics during electrochemical cycling of lithium transition metal olivine compounds
… the most attention for its likelihood to provide low price, good cycling stability, thermal stability, and low-toxicity. It is being utilized in a new generation of Li-ion batteries for high power applications such as power tools and electric vehicles. However, LiFePO4 cathodes also have several …
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Bed Bug Management in Low-Income, Multi-Unit Housing: An Evaluation of Resident Education and Cost-Effective, Minimally Toxic Suppression Methods
… on bed bug suppression in multi-unit housing. Low income, multi-unit housing residents lack basic bed bug knowledge and are particulary vulnerable to bed bug infestations because they are unable to afford conventional treatment. In this study, diatomaceous earth (D.E.), an inexpensive desiccant …
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Complexation Between DNA and Hydrophilic-Cationic Diblock Copolymers
… viral vehicles: high genetic payload capacity, low toxicity, and low cost. Among the many polycation architectures, hydrophilic-cationic diblock copolymers are particularly promising due to their versatility. Compared to the emphasis on biological evaluation of polyplexes, however, in-depth …
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