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Showing 1 to 3 of 3 for “"Low molecular weight cyclin E"”.
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Low Molecular Weight Cyclin E Deregulates Dna Replication and Damage Repair to Promote Genomic Instability In Breast Cancer
<p>Low molecular weight cyclin E (LMW-E) are oncogenic forms of cyclin E that are post translationally generated by neutrophil elastase (NE) mediated cleavage of the 50 KDa full-length cyclin E1 (FL-cycE, encoded by <em>CCNE1</em>gene). The resultant N-terminus deleted (40 amino acids) form of …
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Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… take up NE resulting in increased generation of low molecular weight cyclin E (CCNE) and enhanced susceptibility to lysis by CCNE-specific cytotoxic T lymphocytes. We also show that after taking up NE and proteinase 3 (PR3), a second primary granule protease with significant homology to NE, …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
<p>Cyclin E is altered or overexpressed in approximately one-third of tumors from patients with invasive breast cancer and is a powerful independent predictor for survival in women with stage I-III breast cancer. Full-length cyclin E (EL) is post-translationally cleaved into two …