Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Loss-of-function genetic screens"”.
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Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL3NPH3 ubiquitin ligase complex
Plants are sessile by nature; because of this they have evolved many strategies to cope with the diverse environmental stimuli they encounter in nature. One such strategy is the phototropic response by which plants reorient the aerial organs toward and roots away from directional blue light. The …
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Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase
Loss-of-function genetic screens are a powerful approach to identify the genes involved in biological processes. For nearly a century, forward genetic screens in model organisms have provided enormous insight into many cellular processes. However, the difficulty in generating and recovering …
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In vivo pool-based shRNA screens to identify modulators of disease progression in hematopoietic malignancies
shRNA screens have been very effective in identifying novel cancer genes in mammalian cells, but they have primarily been limited to in vitro applications in tumor cell lines. Whereas in vivo retroviral mutagenesis screens typically identify gain-of-function alterations in positive selection …
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Genome-scale identification of cellular pathways required for cell surface recognition
A range of biochemically diverse molecules located in the plasma membrane - such as proteins, glycans, and lipids - mediate cellular recognition events, initiation of signalling pathways, and the regulation of processes important for the normal development and function of multicellular organisms. …